Simulation of blood flow and oxygen transport in vascular networks

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The ability of the circulatory system to meet the metabolic needs of tissues, including adequate oxygen supply, is sensitively dependent on the geometry of the vascular network and on the distribution of blood flow in the network. Advanced imaging methods can provide information about network structure down to the capillary level in small tissue regions. Based on this information, theoretical simulations provide a means to predict functional parameters such as perfusion and oxygen extraction. Methods have been developed to simulate blood flow and oxygen transport in networks with thousands of segments, even when information about flow and oxygen levels in segments that cross the boundaries of the tissue region is incomplete. Used in combination with experimental approaches, these methods can lead to better understanding of normal vascular functions and of the pathological consequences of vascular dysfunction.

Original languageEnglish (US)
Title of host publicationThe Vasculome
Subtitle of host publicationFrom Many, One
PublisherElsevier
Pages173-179
Number of pages7
ISBN (Electronic)9780128225462
ISBN (Print)9780128225479
DOIs
StatePublished - Jan 1 2022

Keywords

  • Bifurcation
  • Blood viscosity
  • Convection
  • Diffusion
  • Fluid mechanics
  • Microcirculation
  • Theoretical model

ASJC Scopus subject areas

  • Medicine(all)

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