Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Kul Mei; Mel Jin; Shilei Zhang; Ping Li; Wenjing Liu; Xiaobei Chen; Fei Xue; Wenhu Duan; Wei Wang

doi:10.1021/ol9010322

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Kul Mei
, Mel Jin
, Shilei Zhang
, Ping Li
, Wenjing Liu
, Xiaobei Chen
, Fei Xue
, Wenhu Duan
, Wei Wang

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

Original language	English (US)
Pages (from-to)	2864-2867
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	13
DOIs	https://doi.org/10.1021/ol9010322
State	Published - Jul 2 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9010322

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title = "Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones",

abstract = "A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.",

author = "Kul Mei and Mel Jin and Shilei Zhang and Ping Li and Wenjing Liu and Xiaobei Chen and Fei Xue and Wenhu Duan and Wei Wang",

year = "2009",

month = jul,

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doi = "10.1021/ol9010322",

language = "English (US)",

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journal = "Organic Letters",

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T1 - Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

AU - Mei, Kul

AU - Jin, Mel

AU - Zhang, Shilei

AU - Li, Ping

AU - Liu, Wenjing

AU - Chen, Xiaobei

AU - Xue, Fei

AU - Duan, Wenhu

AU - Wang, Wei

PY - 2009/7/2

Y1 - 2009/7/2

N2 - A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

AB - A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

UR - https://www.scopus.com/pages/publications/67649491244

UR - https://www.scopus.com/pages/publications/67649491244#tab=citedBy

U2 - 10.1021/ol9010322

DO - 10.1021/ol9010322

M3 - Article

C2 - 19485350

AN - SCOPUS:67649491244

SN - 1523-7060

VL - 11

SP - 2864

EP - 2867

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Abstract

ASJC Scopus subject areas

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