Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Kul Mei; Mel Jin; Shilei Zhang; Ping Li; Wenjing Liu; Xiaobei Chen; Fei Xue; Wenhu Duan; Wei Wang

doi:10.1021/ol9010322

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Kul Mei, Mel Jin, Shilei Zhang, Ping Li, Wenjing Liu, Xiaobei Chen, Fei Xue, Wenhu Duan, Wei Wang

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

Original language	English (US)
Pages (from-to)	2864-2867
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	13
DOIs	https://doi.org/10.1021/ol9010322
State	Published - Jul 2 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol9010322

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title = "Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones",

abstract = "A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.",

author = "Kul Mei and Mel Jin and Shilei Zhang and Ping Li and Wenjing Liu and Xiaobei Chen and Fei Xue and Wenhu Duan and Wei Wang",

year = "2009",

month = jul,

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doi = "10.1021/ol9010322",

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T1 - Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

AU - Mei, Kul

AU - Jin, Mel

AU - Zhang, Shilei

AU - Li, Ping

AU - Liu, Wenjing

AU - Chen, Xiaobei

AU - Xue, Fei

AU - Duan, Wenhu

AU - Wang, Wei

PY - 2009/7/2

Y1 - 2009/7/2

N2 - A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

AB - A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

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U2 - 10.1021/ol9010322

DO - 10.1021/ol9010322

M3 - Article

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SN - 1523-7060

VL - 11

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JO - Organic Letters

JF - Organic Letters

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ER -

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Abstract

ASJC Scopus subject areas

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