Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

Kul Mei, Mel Jin, Shilei Zhang, Ping Li, Wenjing Liu, Xiaobei Chen, Fei Xue, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.

Original languageEnglish (US)
Pages (from-to)2864-2867
Number of pages4
JournalOrganic Letters
Volume11
Issue number13
DOIs
StatePublished - Jul 2 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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