Simple antifungal metabolites from a marine sponge, Halichondria sp.

Hong yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Three indoles, tryptophol (1), 6-bromoindole-3-carbaldehyde (2), and indole-3-carbaldehyde (3) together with p-hydroxybenzaldehyde (4) and phenylacetamide (5) have been isolated from a marine sponge, Halichondria sp. Their structures were elucidated by spectroscopic methods as well as comparison of spectral data with those reported. This is the first isolation of these five compounds from sponges, of which tryptophol (1) and phenylacetamide (5) were isolated for the first time from marine organisms. These compounds were antifungal against Mortierella ramannianus.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Issue number2
StatePublished - Feb 1994
Externally publishedYes


  • 6-Bromoindole-3-carbaldehyde
  • Antifungal metabolites
  • Halichondria
  • Indole-3-carbaldehyde
  • Phenylacetamide
  • Tryptophol
  • p-Hydroxybenzaldehyde

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology


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