Significance of prosttic intraepithelial neoplasia on prostate needle biopsy

Michael K. Brawer; Steven A. Bigler; Olof E. Sohlberg; Raymond B. Nagle; Paul H. Lange

doi:10.1016/S0090-4295(05)80067-6

Significance of prosttic intraepithelial neoplasia on prostate needle biopsy

Michael K. Brawer, Steven A. Bigler, Olof E. Sohlberg, Raymond B. Nagle, Paul H. Lange

Cancer Center

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138 Scopus citations

Abstract

Prostatic intraepithelial neoplasia (PIN) is a putative premalignantchange in the human prostate. Previously, the spatial association of PIN with invasive carcinoma has been described in the study of total prostatectomies. PIN is frequently recognized in prostate needle biopsy specimens in which no carcinoma is apparent. To further define the potential significance of PIN, we performed repeat ultrasound-guided prostate needle biopsy in 21 men who had PIN identified on prostate biopsy performed because of an abnormal finding on digital rectal examination. Twelve patients (57%) had carcinoma identified on their second procedure including all who had intermediate- and high-grade PIN on the initial procedure. Prostate-specific antigen correlated with PIN grade and carcinoma on the secondary procedure, although this did not achieve statistical significance. Men with PIN on prostate needle biopsy should undergo repeat sampling to exclude missed carcinoma.

Original language	English (US)
Pages (from-to)	103-107
Number of pages	5
Journal	Urology
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/S0090-4295(05)80067-6
State	Published - Aug 1991

ASJC Scopus subject areas

Urology

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title = "Significance of prosttic intraepithelial neoplasia on prostate needle biopsy",

abstract = "Prostatic intraepithelial neoplasia (PIN) is a putative premalignantchange in the human prostate. Previously, the spatial association of PIN with invasive carcinoma has been described in the study of total prostatectomies. PIN is frequently recognized in prostate needle biopsy specimens in which no carcinoma is apparent. To further define the potential significance of PIN, we performed repeat ultrasound-guided prostate needle biopsy in 21 men who had PIN identified on prostate biopsy performed because of an abnormal finding on digital rectal examination. Twelve patients (57%) had carcinoma identified on their second procedure including all who had intermediate- and high-grade PIN on the initial procedure. Prostate-specific antigen correlated with PIN grade and carcinoma on the secondary procedure, although this did not achieve statistical significance. Men with PIN on prostate needle biopsy should undergo repeat sampling to exclude missed carcinoma.",

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AU - Brawer, Michael K.

AU - Bigler, Steven A.

AU - Sohlberg, Olof E.

AU - Nagle, Raymond B.

AU - Lange, Paul H.

PY - 1991/8

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AB - Prostatic intraepithelial neoplasia (PIN) is a putative premalignantchange in the human prostate. Previously, the spatial association of PIN with invasive carcinoma has been described in the study of total prostatectomies. PIN is frequently recognized in prostate needle biopsy specimens in which no carcinoma is apparent. To further define the potential significance of PIN, we performed repeat ultrasound-guided prostate needle biopsy in 21 men who had PIN identified on prostate biopsy performed because of an abnormal finding on digital rectal examination. Twelve patients (57%) had carcinoma identified on their second procedure including all who had intermediate- and high-grade PIN on the initial procedure. Prostate-specific antigen correlated with PIN grade and carcinoma on the secondary procedure, although this did not achieve statistical significance. Men with PIN on prostate needle biopsy should undergo repeat sampling to exclude missed carcinoma.

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Significance of prosttic intraepithelial neoplasia on prostate needle biopsy

Abstract

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