TY - GEN
T1 - Short-wave Photoacoustic Lipid Imaging (SW-PALI) for Detection of early-onset Alzheimer's Disease
AU - Salinas, Christopher M.
AU - Reichel, Eric
AU - Witte, Russell S.
N1 - Funding Information:
ACKNOWLEDGMENTS This work was supported in part by NIH grant R01AR074627. We would also like to thank Prof Beth Hutchison for providing the mouse brain specimen, and the High Frequency Ultrasound Core Facility at the University of Arizona for access to the Vevo 3100 / LAZR-X.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Deficiencies in lipid transport and metabolism in the brain have been shown to increase the risk factor of Alzheimer's disease (AD), indicating that structural changes of lipids in the brain may play a vital role in early-onset AD. It is henceforth important to have the capability of imaging these structural changes of lipids throughout different stages of disease. Currently, there is an unmet need for high spatial resolution (100μm) mapping of lipids in the brain at depths greater than what is obtained using traditional optical methods (>1 mm). We have previously demonstrated the ability of a short-wave infrared (SWIR) photoacoustic (PA) system to spatially map lipid and water (L/W) content in tissue. Here we present the ability of the system to accurately map and predict lipid concentrations at depths of 5mm. L/W mapping of a mouse brain predicts gray and white matter lipid concentrations of 30 ± 9% and 57 ± 3% respectively, which agree with generally accepted values. This work lends itself to the application of future in vivo studies of early-onset AD in mouse models, where noninvasive mapping of L/W would dramatically improve on existing methods for brain imaging of lipid content.
AB - Deficiencies in lipid transport and metabolism in the brain have been shown to increase the risk factor of Alzheimer's disease (AD), indicating that structural changes of lipids in the brain may play a vital role in early-onset AD. It is henceforth important to have the capability of imaging these structural changes of lipids throughout different stages of disease. Currently, there is an unmet need for high spatial resolution (100μm) mapping of lipids in the brain at depths greater than what is obtained using traditional optical methods (>1 mm). We have previously demonstrated the ability of a short-wave infrared (SWIR) photoacoustic (PA) system to spatially map lipid and water (L/W) content in tissue. Here we present the ability of the system to accurately map and predict lipid concentrations at depths of 5mm. L/W mapping of a mouse brain predicts gray and white matter lipid concentrations of 30 ± 9% and 57 ± 3% respectively, which agree with generally accepted values. This work lends itself to the application of future in vivo studies of early-onset AD in mouse models, where noninvasive mapping of L/W would dramatically improve on existing methods for brain imaging of lipid content.
KW - Alzheimer's Disease
KW - Lipids
KW - Photoacoustic
KW - Short-wave Infrared
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U2 - 10.1109/IUS54386.2022.9957485
DO - 10.1109/IUS54386.2022.9957485
M3 - Conference contribution
AN - SCOPUS:85143758615
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2022 - IEEE International Ultrasonics Symposium
PB - IEEE Computer Society
T2 - 2022 IEEE International Ultrasonics Symposium, IUS 2022
Y2 - 10 October 2022 through 13 October 2022
ER -