Short communication: PPARγ mediates a direct antiangiogenic effect of ω3-PUFAs in proliferative retinopathy

Andreas Stahl, Przemyslaw Sapieha, Kip M. Connor, John Paul Sangiovanni, Jing Chen, Christopher M. Aderman, Keirnan L. Willett, Nathan M. Krah, Roberta J. Dennison, Molly R. Seaward, Karen I. Guerin, Jing Hua, Lois E.H. Smith

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Rationale: Omega3 long-chain polyunsaturated fatty acids (ω3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing ω3-PUFA-dependent attenuation of angiogenesis. Objective: This study aims to identify a major mechanism by which ω3-PUFAs attenuate retinal neovascularization. Methods and Results: Administering ω3-PUFAs exclusively during the neovascular stage of the mouse model of oxygen-induced retinopathy induces a direct neovascularization reduction of more than 40% without altering vasoobliteration or the regrowth of normal vessels. Cotreatment with an inhibitor of peroxisome proliferator-activated receptor (PPAR)γ almost completely abrogates this effect. Inhibition of PPARγ also reverses the ω3-PUFA-induced reduction of retinal tumor necrosis factor-α, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial selectin, and angiopoietin 2 but not vascular endothelial growth factor. Conclusions: These results identify a direct, PPARγ-mediated effect of ω3-PUFAs on retinal neovascularization formation and retinal angiogenic activation that is independent of vascular endothelial growth factor.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalCirculation research
Volume107
Issue number4
DOIs
StatePublished - Aug 20 2010
Externally publishedYes

Keywords

  • PPAR
  • neovascularization
  • omega 3 PUFA
  • oxygen-induced retinopathy
  • retinopathy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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