Abstract
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.
Original language | English (US) |
---|---|
Pages (from-to) | 20-25 |
Number of pages | 6 |
Journal | Journal of Biomechanics |
Volume | 50 |
DOIs | |
State | Published - Jan 4 2017 |
Keywords
- Fluid shear stress
- Mechanical circulatory support
- Mechanotransduction
- Platelet activation
- Thrombosis
ASJC Scopus subject areas
- Biophysics
- Rehabilitation
- Biomedical Engineering
- Orthopedics and Sports Medicine