Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

Marvin J. Slepian; Jawaad Sheriff; Marcus Hutchinson; Phat Tran; Naing Bajaj; Joe G.N. Garcia; S. Scott Saavedra; Danny Bluestein

doi:10.1016/j.jbiomech.2016.11.016

Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

Marvin J. Slepian, Jawaad Sheriff, Marcus Hutchinson, Phat Tran, Naing Bajaj, Joe G.N. Garcia, S. Scott Saavedra, Danny Bluestein

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.

Original language	English (US)
Pages (from-to)	20-25
Number of pages	6
Journal	Journal of Biomechanics
Volume	50
DOIs	https://doi.org/10.1016/j.jbiomech.2016.11.016
State	Published - Jan 4 2017

Keywords

Fluid shear stress
Mechanical circulatory support
Mechanotransduction
Platelet activation
Thrombosis

ASJC Scopus subject areas

Biophysics
Orthopedics and Sports Medicine
Biomedical Engineering
Rehabilitation

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10.1016/j.jbiomech.2016.11.016

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Slepian, M. J., Sheriff, J., Hutchinson, M., Tran, P., Bajaj, N., Garcia, J. G. N., Scott Saavedra, S., & Bluestein, D. (2017). Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis. Journal of Biomechanics, 50, 20-25. https://doi.org/10.1016/j.jbiomech.2016.11.016

Slepian, MJ, Sheriff, J, Hutchinson, M, Tran, P, Bajaj, N, Garcia, JGN, Scott Saavedra, S & Bluestein, D 2017, 'Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis', Journal of Biomechanics, vol. 50, pp. 20-25. https://doi.org/10.1016/j.jbiomech.2016.11.016

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title = "Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis",

abstract = "Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.",

keywords = "Fluid shear stress, Mechanical circulatory support, Mechanotransduction, Platelet activation, Thrombosis",

author = "Slepian, {Marvin J.} and Jawaad Sheriff and Marcus Hutchinson and Phat Tran and Naing Bajaj and Garcia, {Joe G.N.} and {Scott Saavedra}, S. and Danny Bluestein",

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AU - Slepian, Marvin J.

AU - Sheriff, Jawaad

AU - Hutchinson, Marcus

AU - Tran, Phat

AU - Bajaj, Naing

AU - Garcia, Joe G.N.

AU - Scott Saavedra, S.

AU - Bluestein, Danny

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AB - Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.

KW - Fluid shear stress

KW - Mechanical circulatory support

KW - Mechanotransduction

KW - Platelet activation

KW - Thrombosis

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Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis

Abstract

Keywords

ASJC Scopus subject areas

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