@article{0c1c6058c00944668a41b2bee70a1412,
title = "Shared Functions of Perirhinal and Parahippocampal Cortices: Implications for Cognitive Aging",
abstract = "A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. However, known anatomical connectivity, together with recent electrophysiological, neuroimaging, and lesion data, indicate that both brain areas participate in spatial and nonspatial processing. Instead of content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical–hippocampal networks: one network that is tuned to process coarse information quickly, forming gist-like representations of scenes/environments, and a second network tuned to process information about the specific sensory details that are necessary for discrimination across sensory modalities. The available data suggest that the latter network may be more vulnerable in advanced age.",
keywords = "MRI, entorhinal cortex, hippocampus, memory, postrhinal cortex, process model",
author = "Burke, {Sara N.} and Gaynor, {Leslie S.} and Barnes, {Carol A.} and Bauer, {Russell M.} and Bizon, {Jennifer L.} and Roberson, {Erik D.} and Lee Ryan",
note = "Funding Information: This work was supported by the McKnight Brain Research Foundation, the Arizona Alzheimer's Consortium, Arizona Department of Health Services (to L.R. and C.A.B.), the Florida Department of Health, Ed and Ethel Moore Alzheimer's Disease Research Program (to J.L.B. and S.N.B.), and National Institutes of Health grants R01AG049722 (to S.N.B.), RO1AG003376 (to C.A.B.), P50 AG077266 (to S.N.B. and R.M.B.), UL1 TR001427 NCATS (to R.M.B.), R01AG029421 (to J.L.B.), and R01NS075487 (to E.D.R.). Funding Information: This work was supported by the McKnight Brain Research Foundation, the Arizona Alzheimer{\textquoteright}s Consortium, Arizona Department of Health Services (to L.R. and C.A.B.), the Florida Department of Health, Ed and Ethel Moore Alzheimer{\textquoteright}s Disease Research Program (to J.L.B. and S.N.B.), and National Institutes of Health grants R01AG049722 (to S.N.B.), RO1AG003376 (to C.A.B.), P50 AG077266 (to S.N.B. and R.M.B.), UL1 TR001427 NCATS (to R.M.B.), R01AG029421 (to J.L.B.), and R01NS075487 (to E.D.R.). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = jun,
doi = "10.1016/j.tins.2018.03.001",
language = "English (US)",
volume = "41",
pages = "349--359",
journal = "Trends in Neurosciences",
issn = "0166-2236",
publisher = "Elsevier Limited",
number = "6",
}