Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

Steve C. Danzer; Robin O. Price; Nathaniel T. McMullen; Naomi E. Rance

doi:10.1016/S0169-328X(99)00024-8

Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

Steve C. Danzer, Robin O. Price, Nathaniel T. McMullen, Naomi E. Rance

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats.

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Molecular Brain Research
Volume	66
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(99)00024-8
State	Published - Mar 20 1999

Keywords

Estrogen
Hypothalamus
Menopause
Reproduction
Testosterone

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(99)00024-8

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title = "Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats",

abstract = "Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats.",

keywords = "Estrogen, Hypothalamus, Menopause, Reproduction, Testosterone",

author = "Danzer, {Steve C.} and Price, {Robin O.} and {T. McMullen}, Nathaniel and Rance, {Naomi E.}",

note = "Funding Information: This work was supported by grant AG-09214 from the National Institute of Health. Steve Danzer was a recipient of a Predoctoral Fellowship from the Robert S. Flinn Biomedical Research Initiative. We thank Keri Kaeding and Ty Abel for useful comments on an earlier version of this manuscript and David A. Frye for excellent technical assistance. Robin Price and David Frye were supported by the Undergraduate Biology Research Program at the University of Arizona. ",

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T1 - Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

AU - Danzer, Steve C.

AU - Price, Robin O.

AU - T. McMullen, Nathaniel

AU - Rance, Naomi E.

N1 - Funding Information: This work was supported by grant AG-09214 from the National Institute of Health. Steve Danzer was a recipient of a Predoctoral Fellowship from the Robert S. Flinn Biomedical Research Initiative. We thank Keri Kaeding and Ty Abel for useful comments on an earlier version of this manuscript and David A. Frye for excellent technical assistance. Robin Price and David Frye were supported by the Undergraduate Biology Research Program at the University of Arizona.

PY - 1999/3/20

Y1 - 1999/3/20

N2 - Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats.

AB - Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats.

KW - Estrogen

KW - Hypothalamus

KW - Menopause

KW - Reproduction

KW - Testosterone

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DO - 10.1016/S0169-328X(99)00024-8

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JO - Molecular Brain Research

JF - Molecular Brain Research

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ER -

Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats

Abstract

Keywords

ASJC Scopus subject areas

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