Sex differences in cognitive estimation during sleep deprivation: Effects of stimulant countermeasures

William D.S. Killgore; Alison E. Muckle; Nancy L. Grugle; Desiree B. Killgore; Thomas J. Balkin

doi:10.1080/00207450802323970

Sex differences in cognitive estimation during sleep deprivation: Effects of stimulant countermeasures

William D.S. Killgore, Alison E. Muckle, Nancy L. Grugle, Desiree B. Killgore, Thomas J. Balkin

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization. The effectiveness of caffeine, modafinil, dextroamphetamine, or placebo for sustaining performance on the Biber Cognitive Estimation Test (BCET) was compared in 29 men and 25 women following 46 hr of sleep deprivation. Stimulants had differential effects on BCET performance as a function of the sex of the subjects. Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men andwomen.

Original language	English (US)
Pages (from-to)	1547-1557
Number of pages	11
Journal	International Journal of Neuroscience
Volume	118
Issue number	11
DOIs	https://doi.org/10.1080/00207450802323970
State	Published - Nov 2008
Externally published	Yes

Keywords

Caffeine
Dextroamphetamine
Executive function
Modafinil
Sleep deprivation
Stimulants

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1080/00207450802323970

Cite this

@article{928d993ffb20494099aebdbe3a6b47ba,

title = "Sex differences in cognitive estimation during sleep deprivation: Effects of stimulant countermeasures",

abstract = "Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization. The effectiveness of caffeine, modafinil, dextroamphetamine, or placebo for sustaining performance on the Biber Cognitive Estimation Test (BCET) was compared in 29 men and 25 women following 46 hr of sleep deprivation. Stimulants had differential effects on BCET performance as a function of the sex of the subjects. Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men andwomen.",

keywords = "Caffeine, Dextroamphetamine, Executive function, Modafinil, Sleep deprivation, Stimulants",

author = "Killgore, {William D.S.} and Muckle, {Alison E.} and Grugle, {Nancy L.} and Killgore, {Desiree B.} and Balkin, {Thomas J.}",

year = "2008",

month = nov,

doi = "10.1080/00207450802323970",

language = "English (US)",

volume = "118",

pages = "1547--1557",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Informa Healthcare",

number = "11",

}

TY - JOUR

T1 - Sex differences in cognitive estimation during sleep deprivation

T2 - Effects of stimulant countermeasures

AU - Killgore, William D.S.

AU - Muckle, Alison E.

AU - Grugle, Nancy L.

AU - Killgore, Desiree B.

AU - Balkin, Thomas J.

PY - 2008/11

Y1 - 2008/11

N2 - Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization. The effectiveness of caffeine, modafinil, dextroamphetamine, or placebo for sustaining performance on the Biber Cognitive Estimation Test (BCET) was compared in 29 men and 25 women following 46 hr of sleep deprivation. Stimulants had differential effects on BCET performance as a function of the sex of the subjects. Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men andwomen.

AB - Stimulant medications restore simple alertness during sleep loss, but it is not clear how they affect complex executive functions, particularly in light of sex differences in cerebral organization. The effectiveness of caffeine, modafinil, dextroamphetamine, or placebo for sustaining performance on the Biber Cognitive Estimation Test (BCET) was compared in 29 men and 25 women following 46 hr of sleep deprivation. Stimulants had differential effects on BCET performance as a function of the sex of the subjects. Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men andwomen.

KW - Caffeine

KW - Dextroamphetamine

KW - Executive function

KW - Modafinil

KW - Sleep deprivation

KW - Stimulants

UR - http://www.scopus.com/inward/record.url?scp=53949104488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53949104488&partnerID=8YFLogxK

U2 - 10.1080/00207450802323970

DO - 10.1080/00207450802323970

M3 - Article

C2 - 18853333

AN - SCOPUS:53949104488

SN - 0020-7454

VL - 118

SP - 1547

EP - 1557

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 11

ER -

Sex differences in cognitive estimation during sleep deprivation: Effects of stimulant countermeasures

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this