Sesquiterpenoids from Coreocarpus arizonicus

Shivanand D. Jolad; Barbara N. Timmermann; Joseph J. Hoffmann; Robert B. Bates; Fernando A. Camou; Jack R. Cole

doi:10.1016/0031-9422(88)80765-9

Sesquiterpenoids from Coreocarpus arizonicus

Shivanand D. Jolad, Barbara N. Timmermann, Joseph J. Hoffmann, Robert B. Bates, Fernando A. Camou, Jack R. Cole

Pharmacy Practice and Science

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6 Scopus citations

Abstract

Ten sesquiterpenoids were isolated from the methylene chloride extract of Coreocarpus arizonicus. Five were new, identified on the basis of spectral data as 1 (R), 4(R), 7(S)- and 1(S), 4(S), 7(S)-bisabol-2-en- 1,4-diols and dimers of perezone (biperezone) and its 12-(2-methylbutyroxyl) and 12-isovaleroxyl derivatives oxidatively coupled through C-4. The known sesquiterpenoids were costunolide, dihydrocostunolide, perezone, α-pipitzol and spathulenol.

Original language	English (US)
Pages (from-to)	3545-3548
Number of pages	4
Journal	Phytochemistry
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/0031-9422(88)80765-9
State	Published - 1988

Keywords

Coreocarpus arizonicus: Asteraceae
Coreopsidinae
Heliantheae
bi-(12-isovaleroxyperezone)
bi-[12-(2-methylbutyroxy)-perezone]
biperezone
bisabolane diols
sesquiterpenoids.

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/0031-9422(88)80765-9

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@article{89d0a425de094960b286e1e077c74fae,

title = "Sesquiterpenoids from Coreocarpus arizonicus",

abstract = "Ten sesquiterpenoids were isolated from the methylene chloride extract of Coreocarpus arizonicus. Five were new, identified on the basis of spectral data as 1 (R), 4(R), 7(S)- and 1(S), 4(S), 7(S)-bisabol-2-en- 1,4-diols and dimers of perezone (biperezone) and its 12-(2-methylbutyroxyl) and 12-isovaleroxyl derivatives oxidatively coupled through C-4. The known sesquiterpenoids were costunolide, dihydrocostunolide, perezone, α-pipitzol and spathulenol.",

keywords = "Coreocarpus arizonicus: Asteraceae, Coreopsidinae, Heliantheae, bi-(12-isovaleroxyperezone), bi-[12-(2-methylbutyroxy)-perezone], biperezone, bisabolane diols, sesquiterpenoids.",

author = "Jolad, {Shivanand D.} and Timmermann, {Barbara N.} and Hoffmann, {Joseph J.} and Bates, {Robert B.} and Camou, {Fernando A.} and Cole, {Jack R.}",

note = "Funding Information: Acknowledyrments~~Wet hank Dr Steven P McLaughlin for plant collection and Identification and Mr Peter Baker for MS data This mvestlgation was supported m part by the Natlonal Science Foundation (Grant{\textquoteright} No 8304771) and the Arizona Disease Control ResearchC ommlsslon (Grant No 8277-OOCOOO-l-l-7C-74933w hom we gratefully acknowledge",

year = "1988",

doi = "10.1016/0031-9422(88)80765-9",

language = "English (US)",

volume = "27",

pages = "3545--3548",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd",

number = "11",

}

TY - JOUR

T1 - Sesquiterpenoids from Coreocarpus arizonicus

AU - Jolad, Shivanand D.

AU - Timmermann, Barbara N.

AU - Hoffmann, Joseph J.

AU - Bates, Robert B.

AU - Camou, Fernando A.

AU - Cole, Jack R.

N1 - Funding Information: Acknowledyrments~~Wet hank Dr Steven P McLaughlin for plant collection and Identification and Mr Peter Baker for MS data This mvestlgation was supported m part by the Natlonal Science Foundation (Grant’ No 8304771) and the Arizona Disease Control ResearchC ommlsslon (Grant No 8277-OOCOOO-l-l-7C-74933w hom we gratefully acknowledge

PY - 1988

Y1 - 1988

N2 - Ten sesquiterpenoids were isolated from the methylene chloride extract of Coreocarpus arizonicus. Five were new, identified on the basis of spectral data as 1 (R), 4(R), 7(S)- and 1(S), 4(S), 7(S)-bisabol-2-en- 1,4-diols and dimers of perezone (biperezone) and its 12-(2-methylbutyroxyl) and 12-isovaleroxyl derivatives oxidatively coupled through C-4. The known sesquiterpenoids were costunolide, dihydrocostunolide, perezone, α-pipitzol and spathulenol.

AB - Ten sesquiterpenoids were isolated from the methylene chloride extract of Coreocarpus arizonicus. Five were new, identified on the basis of spectral data as 1 (R), 4(R), 7(S)- and 1(S), 4(S), 7(S)-bisabol-2-en- 1,4-diols and dimers of perezone (biperezone) and its 12-(2-methylbutyroxyl) and 12-isovaleroxyl derivatives oxidatively coupled through C-4. The known sesquiterpenoids were costunolide, dihydrocostunolide, perezone, α-pipitzol and spathulenol.

KW - Coreocarpus arizonicus: Asteraceae

KW - Coreopsidinae

KW - Heliantheae

KW - bi-(12-isovaleroxyperezone)

KW - bi-[12-(2-methylbutyroxy)-perezone]

KW - biperezone

KW - bisabolane diols

KW - sesquiterpenoids.

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U2 - 10.1016/0031-9422(88)80765-9

DO - 10.1016/0031-9422(88)80765-9

M3 - Article

AN - SCOPUS:45549113344

SN - 0031-9422

VL - 27

SP - 3545

EP - 3548

JO - Phytochemistry

JF - Phytochemistry

IS - 11

ER -

Sesquiterpenoids from Coreocarpus arizonicus

Abstract

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