TY - JOUR
T1 - Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran desert
AU - Wijeratne, E. M.Kithsiri
AU - Paranagama, Priyani A.
AU - Marron, Marilyn T.
AU - Gunatilaka, Malkanthi K.
AU - Arnold, A. Elizabeth
AU - Gunatilaka, A. A.Leslie
PY - 2008/2
Y1 - 2008/2
N2 - Five new metabolites, (+)-(5S,10S)-4′-hydroxymethylcyclozonarone (1), 3-ketotauranin (3), 3α-hydroxytauranin (4), 12-hydroxytauranin (5), and phyllospinarone (6), together with tauranin (2), were isolated from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five cancer cell lines, and only tauranin (2) showed activity. When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines.
AB - Five new metabolites, (+)-(5S,10S)-4′-hydroxymethylcyclozonarone (1), 3-ketotauranin (3), 3α-hydroxytauranin (4), 12-hydroxytauranin (5), and phyllospinarone (6), together with tauranin (2), were isolated from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five cancer cell lines, and only tauranin (2) showed activity. When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines.
UR - http://www.scopus.com/inward/record.url?scp=40549084959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549084959&partnerID=8YFLogxK
U2 - 10.1021/np070600c
DO - 10.1021/np070600c
M3 - Article
C2 - 18247573
AN - SCOPUS:40549084959
SN - 0163-3864
VL - 71
SP - 218
EP - 222
JO - Journal Of Natural Products
JF - Journal Of Natural Products
IS - 2
ER -