Serum proteins in prostatic cancer: V. alterations in immunoglobulins and clinical responsiveness following cryoprostatectomy

Richard J. Ablin, Ward A. Soanes, Maurice J. Gonder

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Levels of the three major serum immunoglobulins (G, A, M) were quantitated prior to and up to 2 weeks following each of two independent freezing treatments of the primary prostatic tumour in 4 patients undergoing remission or healing of their metastatic lesions. Cyclical alterations in the level of IgG accompanied by moderate alterations in the level of IgA were noted post-operatively. Most striking was an almost twofold increase in the level of IgM in 3 of the 4 patients evaluated. While possibly a non-specific association, observations of increased levels of IgG and IgM following cryotherapy may represent an active immunologic response by the host to prostatic tissue (tumour?)-specific or tumour-associated antigen (s) in the form of ‘blocking’ factor (s) or cytotoxic antibody.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalUrologia Internationalis
Volume32
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

Keywords

  • Cryoprostatectomy
  • Cryosurgery
  • Prostatic cancer
  • Serum immunoglobulins (G, A, M)
  • γ-globulin

ASJC Scopus subject areas

  • Urology

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