Serum proteins in prostatic cancer. I. Relationship between clinical stage and level

R. J. Ablin, M. J. Gonder, W. A. Soanes

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

In 23 patients with carcinoma of the prostate the relationship between the clinical stage of malignancy and the level of the major electrophoretic fractions of serum as determined by cellulose acetate electrophoresis and immunoelectrophoresis was studied. The authors observed an increase in the levels of alpha2 and beta globulins in carcinoma patients; furthermore, the percentage of patients possessing elevations of those proteins increased as the prostatic malignancy progressed. While elevations of alpha2 and/or beta globulins are not pathognomonic for prostatic carcinoma, the association of their progressive increase with a progression of malignancy and observations by others of the presence of abnormal serum proteins in patients with epithelial rather than reticuloendothelial neoplasms suggests the usefulness of such analysis in the diagnosis and prognosis of patients with malignancy in determining the possible extent of the disease.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalJournal of Urology
Volume110
Issue number2
DOIs
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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