@article{57ec2da44c2d4707bbab82b5f75a659b,
title = "Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients",
abstract = "A stage I non-small cell lung cancer (NSCLC) serum profiling platform is presented which is highly efficient and accurate. Test sensitivity (0.95) for stage I NSCLC is the highest reported so far. Test metrics are reported for discriminating stage I adenocarcinoma vs squamous cell carcinoma subtypes. Blinded analysis identified 23 out of 24 stage I NSCLC and control serum samples. Group-discriminating mass peaks were targeted for tandem mass spectrometry peptide/protein identification, and yielded a lung cancer phenotype. Bioinformatic analysis revealed a novel lymphocyte adhesion pathway involved with early-stage lung cancer.",
author = "Hocker, {James R.} and Deb, {Subrato J.} and Min Li and Lerner, {Megan R.} and Lightfoot, {Stan A.} and Quillet, {Aurelien A.} and Hanas, {R. Jane} and Matthew Reinersman and Thompson, {Jess L.} and Vu, {Nicole T.} and Kupiec, {Thomas C.} and Brackett, {Daniel J.} and Peyton, {Marvin D.} and Dubinett, {Stephen M.} and Burkhart, {Harold M.} and Postier, {Russell G.} and Hanas, {Jay S.}",
note = "Funding Information: This work was funded by the Oklahoma Center for the Advancement of Science and Technology, the Presbyterian Health Foundation, and the research funds of the University of Oklahoma Departments of Surgery and Biochemistry and Molecular Biology. We thank the Staff of the Department of Surgery for all their ef forts on this study. Funding Information: None of the co-authors have a conflict of interest pertaining to this manuscript. The co-authors have read the manuscript, contributed in an experimental and/or intellectual manner, and agree with its contents. Grant sponsors: Presbyterian Health Foundation, Oklahoma Tobacco Research Center, to J.S.H.; Grant P20RR016478 to A.M.Q., National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Publisher Copyright: {\textcopyright} 2017 Taylor & Francis Group, LLC.",
year = "2017",
month = oct,
day = "21",
doi = "10.1080/07357907.2017.1373120",
language = "English (US)",
volume = "35",
pages = "573--585",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "9",
}