Serotonin: A local regulator in the mammary gland epithelium

Nelson D. Horseman, Robert J. Collier

    Research output: Contribution to journalReview articlepeer-review

    27 Scopus citations


    Serotonin (5-hydroxytryptamine, 5-HT) is a very simple molecule that plays key roles in complex communication mechanisms within the animal body. In the mammary glands, serotonin biosynthesis and secretion are induced in response to dilation of the alveolar spaces. Since its discovery several years ago, mammary 5-HT has been demonstrated to perform two homeostatic functions. First, serotonin regulates lactation and initiates the transition into the earliest phases of involution. Second, serotonin is a local signal that induces parathyroid hormone-related peptide (PTHrP), which allows the mammary gland to drive the mobilization of calcium from the skeleton. These processes use different receptor types, 5-HT7 and 5-HT2, respectively. In this review, we provide synthetic perspectives on the fundamental processes of lactation homeostasis and the adaptation of calcium homeostasis for lactation. We analyze the role of the intrinsic serotonin system in the physiological regulation of the mammary glands. We also consider the importance of the mammary serotonin system in pathologies and therapies associated with lactation and breast cancer.

    Original languageEnglish (US)
    Pages (from-to)353-374
    Number of pages22
    JournalAnnual Review of Animal Biosciences
    StatePublished - Feb 2014


    • breast cancer
    • calcium
    • hypocalcemia
    • lactation
    • prolactin

    ASJC Scopus subject areas

    • Biotechnology
    • Animal Science and Zoology
    • Genetics
    • veterinary(all)


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