Serologic studies in hairy cell leukemia: High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies

Jorge R. Quesada; James Reuben; Roy L. Hopfer; Francis K. Mundon; Evan M. Hersh

doi:10.1016/0145-2126(86)90234-1

Serologic studies in hairy cell leukemia: High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies

Jorge R. Quesada, James Reuben, Roy L. Hopfer, Francis K. Mundon, Evan M. Hersh

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human T-cell lymphotrophic viruses (HTLV). Eighty-three percent of the patients were seropositive for EBV, with a (reciprocal) geometric mean titer (GMT) of 960. Seventy-eight percent of the patients had antibodies to CMV with a GMT of 435. All 21 patients tested for HTLV I and HTLV III were seronegative; only one patient showed detectable antibodies to HTLV II. The potential role of these infections in the physiopathology of HCL is discussed.

Original language	English (US)
Pages (from-to)	1169-1173
Number of pages	5
Journal	Leukemia Research
Volume	10
Issue number	10
DOIs	https://doi.org/10.1016/0145-2126(86)90234-1
State	Published - 1986
Externally published	Yes

Keywords

Epstein-Barr virus
Hairy cell leukemia
cytomegalovirus
human T-cell leukemia viruses
serologic studies
viral antibodies

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/0145-2126(86)90234-1

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title = "Serologic studies in hairy cell leukemia: High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies",

abstract = "Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human T-cell lymphotrophic viruses (HTLV). Eighty-three percent of the patients were seropositive for EBV, with a (reciprocal) geometric mean titer (GMT) of 960. Seventy-eight percent of the patients had antibodies to CMV with a GMT of 435. All 21 patients tested for HTLV I and HTLV III were seronegative; only one patient showed detectable antibodies to HTLV II. The potential role of these infections in the physiopathology of HCL is discussed.",

keywords = "Epstein-Barr virus, Hairy cell leukemia, cytomegalovirus, human T-cell leukemia viruses, serologic studies, viral antibodies",

author = "Quesada, {Jorge R.} and James Reuben and Hopfer, {Roy L.} and Mundon, {Francis K.} and Hersh, {Evan M.}",

year = "1986",

doi = "10.1016/0145-2126(86)90234-1",

language = "English (US)",

volume = "10",

pages = "1169--1173",

journal = "Leukemia Research",

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number = "10",

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T1 - Serologic studies in hairy cell leukemia

T2 - High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies

AU - Quesada, Jorge R.

AU - Reuben, James

AU - Hopfer, Roy L.

AU - Mundon, Francis K.

AU - Hersh, Evan M.

PY - 1986

Y1 - 1986

N2 - Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human T-cell lymphotrophic viruses (HTLV). Eighty-three percent of the patients were seropositive for EBV, with a (reciprocal) geometric mean titer (GMT) of 960. Seventy-eight percent of the patients had antibodies to CMV with a GMT of 435. All 21 patients tested for HTLV I and HTLV III were seronegative; only one patient showed detectable antibodies to HTLV II. The potential role of these infections in the physiopathology of HCL is discussed.

AB - Serum from 60 patients with hairy cell leukemia (HCL) were studied for the presence and the titers of antibodies to Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human T-cell lymphotrophic viruses (HTLV). Eighty-three percent of the patients were seropositive for EBV, with a (reciprocal) geometric mean titer (GMT) of 960. Seventy-eight percent of the patients had antibodies to CMV with a GMT of 435. All 21 patients tested for HTLV I and HTLV III were seronegative; only one patient showed detectable antibodies to HTLV II. The potential role of these infections in the physiopathology of HCL is discussed.

KW - Epstein-Barr virus

KW - Hairy cell leukemia

KW - cytomegalovirus

KW - human T-cell leukemia viruses

KW - serologic studies

KW - viral antibodies

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Serologic studies in hairy cell leukemia: High prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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