Sequestosome 1/p62: A multi-domain protein with multi-faceted functions

Xiaoyan Liu, Jozsef Gal, Haining Zhu

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The Sequestosome 1/p62 protein has been implicated in the regulation of a multitude of cellular processes such as NF-κB signaling, NRF2-driven oxidative stress response, protein turnover through the ubiquitin-proteasome pathway and the autophagosome/lysosome pathway, apoptosis and cellular metabolism. The domain structure of p62 also reflects this functional complexity since the protein appears to be a mosaic of protein interaction domains and motifs. Deregulation of the level and function of p62 and/or p62 mutations have been linked to a number of human diseases including Paget's disease of the bone, obesity, liver diseases, tumorigenesis and neurodegenerative diseases such as amyotrophic lateral sclerosis and Alzheimer's disease. In this article, we review the current understanding of the involvement of p62 in cellular processes under physiologic and pathological conditions.

Original languageEnglish (US)
Pages (from-to)189-201
Number of pages13
JournalFrontiers in Biology
Volume7
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • amyotrophic lateral sclerosis
  • autophagy
  • NF-κB signaling
  • Paget's disease of bone
  • sequestosome 1/p62
  • ubiquitin-proteasome system

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

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