Abstract
To identify genes responsible for the susceptibility for schizophrenia, and to test the hypothesis that schizophrenia is etiologically heterogeneous, we have studied 39 multiplex families from a systematic sample of schizophrenic patients. Using a complex autosomal dominant model, which considers only those with a diagnosis of schizophrenia or schizoaffective disorder as affected, a random search of the genome for detection of linkage was undertaken. Pairwise linkage analyses suggest a potential linkage (LRH = 34.7 or maximum lod score = 1.54) for one region (22q12-q13.1). Reanalyses, varying parameters in the dominant model, maximized the LRH at 660.7 (maximum lod score 2.82). This finding is of sufficient interest to warrant further investigation through collaborative studies.
Original language | English (US) |
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Pages (from-to) | 36-43 |
Number of pages | 8 |
Journal | American journal of medical genetics |
Volume | 54 |
Issue number | 1 |
DOIs | |
State | Published - 1994 |
Externally published | Yes |
Keywords
- genetic linkage analysis
- heterogeneity
- human chromosome 22
- random search
- schizophrenia
ASJC Scopus subject areas
- Genetics(clinical)