TY - JOUR
T1 - Sequential protein kinase reactions controlling cell growth and differentiation
AU - Johnson, Gary L.
AU - Vaillancourt, Richard R.
PY - 1994/4
Y1 - 1994/4
N2 - Sequential protein kinase reactions involve the phosphorylation and activation of multiple kinases in a pathway. The growth factor receptor tyrosine kinase regulation of the mitogen-activated protein kinase (MAPK) pathway was defined in 1993. The MAPK pathway involves sequential protein kinase reactions. Notable advances were made in defining tyrosine kinase receptor regulation of Ras, and these discoveries were combined with the identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP.
AB - Sequential protein kinase reactions involve the phosphorylation and activation of multiple kinases in a pathway. The growth factor receptor tyrosine kinase regulation of the mitogen-activated protein kinase (MAPK) pathway was defined in 1993. The MAPK pathway involves sequential protein kinase reactions. Notable advances were made in defining tyrosine kinase receptor regulation of Ras, and these discoveries were combined with the identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP.
UR - http://www.scopus.com/inward/record.url?scp=0028333768&partnerID=8YFLogxK
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U2 - 10.1016/0955-0674(94)90141-4
DO - 10.1016/0955-0674(94)90141-4
M3 - Article
C2 - 8024815
AN - SCOPUS:0028333768
SN - 0955-0674
VL - 6
SP - 230
EP - 238
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 2
ER -