Sequential protein kinase reactions controlling cell growth and differentiation

Gary L. Johnson, Richard R. Vaillancourt

Research output: Contribution to journalArticlepeer-review

307 Scopus citations


Sequential protein kinase reactions involve the phosphorylation and activation of multiple kinases in a pathway. The growth factor receptor tyrosine kinase regulation of the mitogen-activated protein kinase (MAPK) pathway was defined in 1993. The MAPK pathway involves sequential protein kinase reactions. Notable advances were made in defining tyrosine kinase receptor regulation of Ras, and these discoveries were combined with the identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP.

Original languageEnglish (US)
Pages (from-to)230-238
Number of pages9
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1994

ASJC Scopus subject areas

  • Cell Biology


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