TY - JOUR
T1 - Sequential effects of aerobic exercise training and weight loss on risk factors for coronary disease in healthy, obese middle-aged and older men
AU - Katzel, Leslie I.
AU - Bleecker, Eugene R.
AU - Rogus, Ellen M.
AU - Goldberg, Andrew P.
N1 - Funding Information:
From the Deparrmem of Medicine. Divisions of Gerontology and Pulmonary Medicine, Universi O, of Maryland School of Medicine. Baltimore: and Baltimore Veterans Affairs Medical Center. Geriatrics Research. Education. and Clinical Center. Baltimore. MD. Submitted January 3, 1997: accepted May 14. 199Z Supported by National Institute on Aging Clinical lnvestigator Award No. 5-KO8-AGO0497 ,L.LK.). a Veterans Affairs Regional Advisory Group grant (L.LK.). National Institutes of Health Grant No. RO1-AG07660-04 'A.RG.I, Johns Hopkins Academic Teaching Nursing Home Award No. PO1-AG04402. General Clinical Research Center Grant No. MO1-RR02719-06. and the Veterans Affairs Geriatric Research. Education. and Clinical Centel: Address reprint requests to Leslie L Katzel. MD. PhD. Baltimore VA Medical Center Geriatrics Service/GRECC (18,. 10 N Greene St. Baltimore. MD 21201. Copyright © 1997 by W.B. Saunders Company 0026-0495/97/4612-0012503.00/0
PY - 1997
Y1 - 1997
N2 - The relative benefits of weight loss (WL) versus aerobic exercise training (AEX) on cardiac risk factors in obese individuals remain controversial. In this study, we examined the effects of the sequential interventions of 9 months of AEX followed by weight loss with continued AEX (AEX + WL) on cardiac risk factors in 21 obese (body fat, 29.5% ± 0.8%, mean ± SEM) middle-aged and older men. AEX increased the maximal aerobic capacity ([V̇O2max] in liters per minute) of these man by 14% (P < .001), with no significant change in weight. AEX did not improve blood pressure (BP) or oral glucose tolerance, and had no significant effect on lipid concentrations. During the AEX + WL intervention, the 21 men lost 8.1 ± 0.6 kg. Despite continued training, there was no further increase in V̇O2max during this intervention. Compared with AEX, AEX + WL decreased glucose and insulin responses during the oral glucose tolerance test (OGTT) by 8% (P < .05) and 30% (P < .01), respectively. AEX + WL reduced plasma triglyceride (TG) by 17% (P < .05) and low-density lipoprotein cholesterol (LDL-C) by 8% (P < .01) and increased high-density lipoprotein cholesterol (HDL-C) by 11% (3.7 mg/dL, P < .01). The sequential interventions resulted in a 20% decrease in the LDL- C/HDL-C ratio. The results demonstrate that AEX + WL had a more substantial impact than AEX alone on glucose tolerance and lipoprotein concentrations. Physicians should encourage obese patients to become physically active and lose weight to improve their cardiac risk factor profile.
AB - The relative benefits of weight loss (WL) versus aerobic exercise training (AEX) on cardiac risk factors in obese individuals remain controversial. In this study, we examined the effects of the sequential interventions of 9 months of AEX followed by weight loss with continued AEX (AEX + WL) on cardiac risk factors in 21 obese (body fat, 29.5% ± 0.8%, mean ± SEM) middle-aged and older men. AEX increased the maximal aerobic capacity ([V̇O2max] in liters per minute) of these man by 14% (P < .001), with no significant change in weight. AEX did not improve blood pressure (BP) or oral glucose tolerance, and had no significant effect on lipid concentrations. During the AEX + WL intervention, the 21 men lost 8.1 ± 0.6 kg. Despite continued training, there was no further increase in V̇O2max during this intervention. Compared with AEX, AEX + WL decreased glucose and insulin responses during the oral glucose tolerance test (OGTT) by 8% (P < .05) and 30% (P < .01), respectively. AEX + WL reduced plasma triglyceride (TG) by 17% (P < .05) and low-density lipoprotein cholesterol (LDL-C) by 8% (P < .01) and increased high-density lipoprotein cholesterol (HDL-C) by 11% (3.7 mg/dL, P < .01). The sequential interventions resulted in a 20% decrease in the LDL- C/HDL-C ratio. The results demonstrate that AEX + WL had a more substantial impact than AEX alone on glucose tolerance and lipoprotein concentrations. Physicians should encourage obese patients to become physically active and lose weight to improve their cardiac risk factor profile.
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U2 - 10.1016/S0026-0495(97)90145-1
DO - 10.1016/S0026-0495(97)90145-1
M3 - Article
C2 - 9439540
AN - SCOPUS:0031436189
SN - 0026-0495
VL - 46
SP - 1441
EP - 1447
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 12
ER -