Abstract
This study was aimed at determining whether patient- or antidepressant-related variables are most important to the mood response to serotonin (5-HT) or catecholamine depletion. Depressed patients treated with open-label mirtazapine (≥ 6 wk) received two depletion tests (5-HT and catecholamine depletion) 1 wk apart. Both 5-HT and catecholamine depletion led to a partial return of depression in most patients. Antidepressant response to mirtazapine is dependent on its dual actions on norepinephrine and 5-HT neurotransmission. Mood response to tryptophan or catecholamine depletion is dependent on the pharmacological properties of the antidepressant being taken during depletion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 63-66 |
| Number of pages | 4 |
| Journal | International Journal of Neuropsychopharmacology |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- Antidepressant
- Major depression
- Neurotransmitter depletion
- Norepinephrine
- Selective serotonin reuptake inhibitors
- Sexual dysfunction
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health
- Pharmacology (medical)
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