Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

Pedro L. Delgado, Francisco A. Moreno, Larry Onate, Alan J. Gelenberg

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


This study was aimed at determining whether patient- or antidepressant-related variables are most important to the mood response to serotonin (5-HT) or catecholamine depletion. Depressed patients treated with open-label mirtazapine (≥ 6 wk) received two depletion tests (5-HT and catecholamine depletion) 1 wk apart. Both 5-HT and catecholamine depletion led to a partial return of depression in most patients. Antidepressant response to mirtazapine is dependent on its dual actions on norepinephrine and 5-HT neurotransmission. Mood response to tryptophan or catecholamine depletion is dependent on the pharmacological properties of the antidepressant being taken during depletion.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalInternational Journal of Neuropsychopharmacology
Issue number1
StatePublished - 2002


  • Antidepressant
  • Major depression
  • Neurotransmitter depletion
  • Norepinephrine
  • Selective serotonin reuptake inhibitors
  • Sexual dysfunction

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients'. Together they form a unique fingerprint.

Cite this