Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

Pedro L. Delgado; Francisco A. Moreno; Larry Onate; Alan J. Gelenberg

doi:10.1017/S1461145702002778

Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

Pedro L. Delgado, Francisco A. Moreno, Larry Onate, Alan J. Gelenberg

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23 Scopus citations

Abstract

This study was aimed at determining whether patient- or antidepressant-related variables are most important to the mood response to serotonin (5-HT) or catecholamine depletion. Depressed patients treated with open-label mirtazapine (≥ 6 wk) received two depletion tests (5-HT and catecholamine depletion) 1 wk apart. Both 5-HT and catecholamine depletion led to a partial return of depression in most patients. Antidepressant response to mirtazapine is dependent on its dual actions on norepinephrine and 5-HT neurotransmission. Mood response to tryptophan or catecholamine depletion is dependent on the pharmacological properties of the antidepressant being taken during depletion.

Original language	English (US)
Pages (from-to)	63-66
Number of pages	4
Journal	International Journal of Neuropsychopharmacology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1017/S1461145702002778
State	Published - 2002

Keywords

Antidepressant
Major depression
Neurotransmitter depletion
Norepinephrine
Selective serotonin reuptake inhibitors
Sexual dysfunction

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1017/S1461145702002778

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Sequential catecholamine and serotonin depletion in mirtazapine-treated depressed patients

Abstract

Keywords

ASJC Scopus subject areas

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