@article{c77f9439c6384375a3a3fe6118dcce2f,
title = "Sensing the environment: A historical perspective on integrin signal transduction",
abstract = "Cell adhesion mediated by integrin receptors has a critical function in organizing cells in tissues and in guiding haematopoietic cells to their sites of action. However, integrin adhesion receptors have broader functions in regulating cell behaviour through their ability to transduce bi-directional signals into and out of the cell and to engage in reciprocal interactions with other cellular receptors. This historical perspective traces the key findings that have led to our current understanding of these important functions of integrins.",
author = "Miranti, {Cindy K.} and Brugge, {Joan S.}",
note = "Funding Information: ACKNOWLEDGEMENTS The authors acknowledge that there are many reports that illustrate the concepts presented in this review, a considerable number of which could not be included because of space limitations. These restrictions limited the extent to which all relevant reports could be cited. The authors would like to thank S. Shattil, M. Schwartz, R. Hynes, A. Putnam and the anonymous referee for helpful suggestions. JSB is supported by the American Cancer Society, National Cancer Institute, Aventis Pharmaceuticals, and Breast Cancer Research Foundation. CKM is supported by the Van Andel Research Institute. Correspondence should be addressed to J.S.B. Supplementary information is available on Nature Cell Biology{\textquoteright}s website (http://cellbio.nature.com).",
year = "2002",
doi = "10.1038/ncb0402-e83",
language = "English (US)",
volume = "4",
pages = "E83--E90",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Research",
number = "4",
}