Senescent synapses and hippocampal circuit dynamics

Sara N. Burke, Carol A. Barnes

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations


Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and in CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated impairments in experimentally-induced plasticity in each of these primary hippocampal subregions. In CA1, plasticity evoked by stimulation shares common mechanisms with the synaptic modification observed following natural behavior. Aging results in deficits in both artificially- and behaviorally-induced plasticity, and this could in part reflect age-related changes in Ca2+ homeostasis. Other observations, however, suggest that increased intracellular Ca2+ levels are beneficial under some circumstances. This review focuses on age-associated changes in synaptic function, how these alterations might contribute to cognitive decline, and the extent to which altered hippocampal circuit properties are detrimental or reflect compensatory processes.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalTrends in Neurosciences
Issue number3
StatePublished - Mar 2010

ASJC Scopus subject areas

  • General Neuroscience


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