TY - JOUR
T1 - Self-reported memory problems in adult-onset cancer survivors
T2 - Effects of cardiovascular disease and insomnia
AU - Jean-Pierre, Pascal
AU - Grandner, Michael A.
AU - Garland, Sheila N.
AU - Henry, Elizabeth
AU - Jean-Louis, Girardin
AU - Burish, Thomas G.
N1 - Funding Information:
Dr. Pascal Jean-Pierre acknowledges the support of the Walther Cancer Foundation . This publication was made possible in part by the National Institutes of Health , National Center for Advancing Translational Sciences , Clinical and Translational Sciences Award Grant Number KL2 TR000163 , to Dr. Pascal Jean-Pierre, PhD, MPH (A. Shekhar, PI). Dr. Michael Grandner wishes to acknowledge funding from the National Heart, Lung, and Blood Institute ( K23HL110216 ), the National Institute of Environmental Health Sciences ( R21ES022931 ), and the Penn Clinical and Translational Research Center and Institute of Translational Medicine and Therapeutics, funded by the Clinical and Translational Sciences Award ( UL1RR024134 ). Dr. Sheila Garland is a postdoctoral fellow funded by a Canadian Institutes for Health Research (CIHR) Bisby Fellowship. Dr. Girardin's contribution was supported by NIH grants R01MD007716 and U54NS081765 .
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background: Cancer and its treatments can deleteriously affect memory. Cardiac function and insomnia can exacerbate memory problems. Objective: To examine the relationships among cardiovascular disease, insomnia, and self-reported memory problems (SRMP) in adult-onset cancer survivors. Methods: We included data from participants (41-64 year-old) of the 2007-2008 National Health and Nutrition Examination Survey, a nationally representative probability sample of the civilian, non-institutionalized population of the US. We excluded participants with brain cancer/stroke history since these conditions are expected to cause cognitive problems. Using binary logistic regression, we determined the prevalence of SRMP relative to cardiac problems and insomnia by weighting our results proportionally. We adjusted for predictors of memory problems: age, sex, race, education and general health. Results: The sample included 2289 adults (49% females), 9% with a cancer history. The results pertain only to cancer survivors. Those with insomnia were 16 times as likely to have SRMP. Only insomnia symptoms (OR, 15.74; 95% CI, 1.73-143.30; p < 0.01) significantly predicted SRMP, uniquely explaining 12% of the variance. Insomnia accounted for 18.8% of the association between cardiac issues and SRMP, demonstrating mediation (Sobel p < 0.05). The large CI is a consequence of analyzing a sub-group of a subpopulation. Among participants without a cancer history, cardiovascular disease and insomnia were not associated with SRMP (. p > 0.05). Limitations: We could not determine severity and time-related changes in SRMP. Conclusion: Likelihood of SRMP was higher in cancer survivors with a history of cardiovascular disease and insomnia symptoms. Future studies are needed to delineate the cardiac-insomnia-memory interrelationships.
AB - Background: Cancer and its treatments can deleteriously affect memory. Cardiac function and insomnia can exacerbate memory problems. Objective: To examine the relationships among cardiovascular disease, insomnia, and self-reported memory problems (SRMP) in adult-onset cancer survivors. Methods: We included data from participants (41-64 year-old) of the 2007-2008 National Health and Nutrition Examination Survey, a nationally representative probability sample of the civilian, non-institutionalized population of the US. We excluded participants with brain cancer/stroke history since these conditions are expected to cause cognitive problems. Using binary logistic regression, we determined the prevalence of SRMP relative to cardiac problems and insomnia by weighting our results proportionally. We adjusted for predictors of memory problems: age, sex, race, education and general health. Results: The sample included 2289 adults (49% females), 9% with a cancer history. The results pertain only to cancer survivors. Those with insomnia were 16 times as likely to have SRMP. Only insomnia symptoms (OR, 15.74; 95% CI, 1.73-143.30; p < 0.01) significantly predicted SRMP, uniquely explaining 12% of the variance. Insomnia accounted for 18.8% of the association between cardiac issues and SRMP, demonstrating mediation (Sobel p < 0.05). The large CI is a consequence of analyzing a sub-group of a subpopulation. Among participants without a cancer history, cardiovascular disease and insomnia were not associated with SRMP (. p > 0.05). Limitations: We could not determine severity and time-related changes in SRMP. Conclusion: Likelihood of SRMP was higher in cancer survivors with a history of cardiovascular disease and insomnia symptoms. Future studies are needed to delineate the cardiac-insomnia-memory interrelationships.
KW - Cancer and memory problems
KW - Cardiovascular disease
KW - Chemobrain
KW - Sleep problems
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U2 - 10.1016/j.sleep.2015.02.531
DO - 10.1016/j.sleep.2015.02.531
M3 - Article
C2 - 26026625
AN - SCOPUS:84930575746
VL - 16
SP - 845
EP - 849
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 7
ER -