Abstract
We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1 MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0.70 mm, a detection threshold of 1.75 mA at 1 MPa and a sensitivity of 0.52 ± 0.07 μV/(mA*MPa). Monopole and dipole configurations in saline were repeated through a human skullcap. Despite 13.8-dB ultrasound attenuation through bone, acoustoelectric imaging was still >10 dB above background with a sensitivity of 0.56 ± 0.10 μV/(mA*MPa). This proof-of-concept study indicates that selective mapping of lead currents through a DBS device may be possible using non-invasive acoustoelectric imaging.
Original language | English (US) |
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Pages (from-to) | 2345-2357 |
Number of pages | 13 |
Journal | Ultrasound in Medicine and Biology |
Volume | 44 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2018 |
Keywords
- Acoustoelectric effect
- Current source density
- Deep brain stimulation
- Essential tremor
- Parkinson's
- Transcranial
- Ultrasound imaging
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Biophysics
- Acoustics and Ultrasonics