Selective Mapping of Deep Brain Stimulation Lead Currents Using Acoustoelectric Imaging

Chet Preston, Willard S. Kasoff, Russell S. Witte

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We describe a new application of acoustoelectric imaging for non-invasive mapping of the location, magnitude and polarity of current generated by a clinical deep brain stimulation (DBS) device. Ultrasound at 1 MHz was focused near the DBS device as short current pulses were injected across different DBS leads. A recording electrode detected the high-frequency acoustoelectric interaction signal. Linear scans of the US beam produced time-varying images of the magnitude and polarity of the induced current, enabling precise localization of the DBS leads within 0.70 mm, a detection threshold of 1.75 mA at 1 MPa and a sensitivity of 0.52 ± 0.07 μV/(mA*MPa). Monopole and dipole configurations in saline were repeated through a human skullcap. Despite 13.8-dB ultrasound attenuation through bone, acoustoelectric imaging was still >10 dB above background with a sensitivity of 0.56 ± 0.10 μV/(mA*MPa). This proof-of-concept study indicates that selective mapping of lead currents through a DBS device may be possible using non-invasive acoustoelectric imaging.

Original languageEnglish (US)
Pages (from-to)2345-2357
Number of pages13
JournalUltrasound in Medicine and Biology
Issue number11
StatePublished - Nov 2018


  • Acoustoelectric effect
  • Current source density
  • Deep brain stimulation
  • Essential tremor
  • Parkinson's
  • Transcranial
  • Ultrasound imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


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