Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate

Linna Zhou; Wenjing Wang; Li Zuo; Shanyan Yao; Wei Wang; Wenhu Duan

doi:10.1016/j.tetlet.2008.06.007

Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate

Linna Zhou, Wenjing Wang, Li Zuo, Shanyan Yao, Wei Wang, Wenhu Duan

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A new debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate is described. The process proceeds selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, COOMe, aldehyde, ketone, and tosyl.

Original language	English (US)
Pages (from-to)	4876-4878
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2008.06.007
State	Published - Aug 11 2008
Externally published	Yes

Keywords

Aromatic benzyl ethers
Debenzylation
Silica-supported
Sodium hydrogen sulfate

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2008.06.007

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title = "Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate",

abstract = "A new debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate is described. The process proceeds selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, COOMe, aldehyde, ketone, and tosyl.",

keywords = "Aromatic benzyl ethers, Debenzylation, Silica-supported, Sodium hydrogen sulfate",

author = "Linna Zhou and Wenjing Wang and Li Zuo and Shanyan Yao and Wei Wang and Wenhu Duan",

note = "Funding Information: We are grateful for financial support from National Natural Science Foundation of China (0801031005), Chinese National Programs for High Technology Research and Development (0604071005 and 0704051005), and the New Drug Basic Research Program of the Shanghai Institute of Materia Medica (07G603B005). ",

year = "2008",

month = aug,

day = "11",

doi = "10.1016/j.tetlet.2008.06.007",

language = "English (US)",

volume = "49",

pages = "4876--4878",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "33",

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TY - JOUR

T1 - Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate

AU - Zhou, Linna

AU - Wang, Wenjing

AU - Zuo, Li

AU - Yao, Shanyan

AU - Wang, Wei

AU - Duan, Wenhu

N1 - Funding Information: We are grateful for financial support from National Natural Science Foundation of China (0801031005), Chinese National Programs for High Technology Research and Development (0604071005 and 0704051005), and the New Drug Basic Research Program of the Shanghai Institute of Materia Medica (07G603B005).

PY - 2008/8/11

Y1 - 2008/8/11

N2 - A new debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate is described. The process proceeds selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, COOMe, aldehyde, ketone, and tosyl.

AB - A new debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate is described. The process proceeds selectively and efficiently in good to excellent yields without affecting sensitive functional groups such as nitro, COOMe, aldehyde, ketone, and tosyl.

KW - Aromatic benzyl ethers

KW - Debenzylation

KW - Silica-supported

KW - Sodium hydrogen sulfate

UR - http://www.scopus.com/inward/record.url?scp=46249127292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46249127292&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.06.007

DO - 10.1016/j.tetlet.2008.06.007

M3 - Article

AN - SCOPUS:46249127292

SN - 0040-4039

VL - 49

SP - 4876

EP - 4878

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Selective debenzylation of aromatic benzyl ethers by silica-supported sodium hydrogen sulfate

Abstract

Keywords

ASJC Scopus subject areas

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