Secretory traffic in the eukaryotic parasite Toxoplasma gondii: Less is more

Keith A. Joiner, David S. Roos

Research output: Contribution to journalShort surveypeer-review

121 Scopus citations


Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple, polarized secretory apparatus with a well-defined endoplasmic reticulum and Golgi that can serve as a model for understanding secretion. Got it? Now name a cell with all these attributes that contains at least a dozen distinct and morphologically well-defined intracellular organelles, including three distinct types of secretory vesicles and two endosymbiotic organelles. Not so sure anymore?

Original languageEnglish (US)
Pages (from-to)557-563
Number of pages7
JournalJournal of Cell Biology
Issue number4
StatePublished - May 13 2002


  • Apicomplexan parasites
  • Eukaryotic evolution
  • Protozoan cell biology
  • Secretory pathway
  • Vesicular trafficking

ASJC Scopus subject areas

  • Cell Biology


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