Second-look laparotomy and salvage therapy: A research modality only?

Mark E. Potter, Kenneth D. Hatch, Seng Jaw Soong, Edward E. Partridge, J. Maxwell Austin, Hugh M. Shingleton

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Two hundred twelve patients who underwent second-look laparotomy as part of their treatment for epithelial ovarian cancer were evaluated. Factors associated with positive second looks were initial stage, tumor grade, age, and residual disease (P < 0.05). One factor not of significance was whether adjuvant therapy was platinum based. Initial stage only was associated with recurrence after a negative second look (P < 0.001). When controlled for volume of disease no difference in survival between various salvage therapies could be demonstrated. Survival between patients with recurrence after negative second look and patients with microscopic residual disease was similar even though the former group was not treated until recurrence (P = 0.75). Second-look laparotomy does not improve survival with currently existing salvage modalities and should primarily be confined to those patients willing to participate in research protocols evaluating new second-line therapy.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalGynecologic oncology
Issue number1
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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