TY - JOUR
T1 - Screening older adults for amnestic mild cognitive impairment and early-stage Alzheimer’s disease using upper-extremity dual-tasking
AU - Toosizadeh, Nima
AU - Ehsani, Hossein
AU - Wendel, Christopher S
AU - Zamrini, Edward
AU - Connor, Kathy O.
AU - Mohler, Martha J
N1 - Funding Information:
This project was supported by an award from the National Institute of Aging (NIA) (award number: 1 R21 AG055852-01). The findings of this manuscript are those of the authors and do not necessarily represent the official views of NIA. Thanks to Sarah Fakhoury, Daniel Gaytan-Jenkins, and Anthony Lopez for data collection, and to Banner Sun Health Research Institute’s Longevity Study participants for their generous participation.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The purpose of the current study was to develop an objective tool based on dual-task performance for screening early-stage Alzheimer’s disease (AD) and mild cognitive impairment (MCI of the Alzheimer’s type). Dual-task involved a simultaneous execution of a sensor-based upper-extremity function (UEF) motor task (normal or rapid speed) and a cognitive task of counting numbers backward (by ones or threes). Motor function speed and variability were recorded and compared between cognitive groups using ANOVAs, adjusted for age, gender, and body mass index. Cognitive indexes were developed using multivariable ordinal logistic models to predict the cognitive status using UEF parameters. Ninety-one participants were recruited; 35 cognitive normal (CN, age = 83.8 ± 6.9), 34 MCI (age = 83.9 ± 6.6), and 22 AD (age = 84.1 ± 6.1). Flexion number and sensor-based motion variability parameters, within the normal pace elbow flexion, showed significant between-group differences (maximum effect size of 1.10 for CN versus MCI and 1.39 for CN versus AD, p < 0.0001). Using these parameters, the cognitive status (both MCI and AD) was predicted with a receiver operating characteristic area under curve of 0.83 (sensitivity = 0.82 and specificity = 0.72). Findings suggest that measures of motor function speed and accuracy within a more practical upper-extremity test (instead of walking) may provide enough complexity for cognitive impairment assessment.
AB - The purpose of the current study was to develop an objective tool based on dual-task performance for screening early-stage Alzheimer’s disease (AD) and mild cognitive impairment (MCI of the Alzheimer’s type). Dual-task involved a simultaneous execution of a sensor-based upper-extremity function (UEF) motor task (normal or rapid speed) and a cognitive task of counting numbers backward (by ones or threes). Motor function speed and variability were recorded and compared between cognitive groups using ANOVAs, adjusted for age, gender, and body mass index. Cognitive indexes were developed using multivariable ordinal logistic models to predict the cognitive status using UEF parameters. Ninety-one participants were recruited; 35 cognitive normal (CN, age = 83.8 ± 6.9), 34 MCI (age = 83.9 ± 6.6), and 22 AD (age = 84.1 ± 6.1). Flexion number and sensor-based motion variability parameters, within the normal pace elbow flexion, showed significant between-group differences (maximum effect size of 1.10 for CN versus MCI and 1.39 for CN versus AD, p < 0.0001). Using these parameters, the cognitive status (both MCI and AD) was predicted with a receiver operating characteristic area under curve of 0.83 (sensitivity = 0.82 and specificity = 0.72). Findings suggest that measures of motor function speed and accuracy within a more practical upper-extremity test (instead of walking) may provide enough complexity for cognitive impairment assessment.
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U2 - 10.1038/s41598-019-46925-y
DO - 10.1038/s41598-019-46925-y
M3 - Article
C2 - 31358792
AN - SCOPUS:85069927947
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 10911
ER -