Science to practice: How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?

Evan C. Unger

doi:10.1148/radiol.2451070872

Science to practice: How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?

Evan C. Unger

Cancer Center

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.

Original language	English (US)
Pages (from-to)	1-2
Number of pages	2
Journal	Radiology
Volume	245
Issue number	1
DOIs	https://doi.org/10.1148/radiol.2451070872
State	Published - Oct 2007

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiol.2451070872

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abstract = "Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.",

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AB - Jacquier et al have shown with magnetic resonance (MR) imaging that therapy with direct intracardiac injection of vascular endothelial growth factor gene (VEGF) improves myocardial function in a model of myocardial infarction in swine. Jacquier and colleagues used MR imaging to measure left ventricular (LV) function and strain and showed that animals treated with gene therapy had stable ejection fraction whereas control animals deteriorated.

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Science to practice: How can cardiac MR imaging help guide development of gene therapy for treatment of coronary heart disease?

Abstract

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