Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin; Annalisa Di Ruscio; Mailin Li; Simone Ummarino; Andreas Hedblom; Reeham Choudhury; Agnieszka Krzyzanowska; Eva Csizmadia; Macarena Palominos; Anna Stiehm; Alexander Ebralidze; Shao Yong Chen; Mahmoud A. Bassal; Ping Zhao; Emanuela Tolosano; Laurence Hurley; Anders Bjartell; Daniel G. Tenen; Barbara Wegiel

doi:10.1016/j.celrep.2020.108181

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin
, Annalisa Di Ruscio
, Mailin Li
, Simone Ummarino
, Andreas Hedblom
, Reeham Choudhury
, Agnieszka Krzyzanowska
, Eva Csizmadia
, Macarena Palominos
, Anna Stiehm
, Alexander Ebralidze
, Shao Yong Chen
, Mahmoud A. Bassal
, Ping Zhao
, Emanuela Tolosano
, Laurence Hurley
, Anders Bjartell
, Daniel G. Tenen
, Barbara Wegiel

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

Original language	English (US)
Article number	108181
Journal	Cell Reports
Volume	32
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2020.108181
State	Published - Sep 22 2020

Keywords

DNA G-quadruplexes
c-myc
heme
heme oxygenase-1
hemopexin
metastases
prostate cancer

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.108181

Cite this

Canesin, G., Di Ruscio, A., Li, M., Ummarino, S., Hedblom, A., Choudhury, R., Krzyzanowska, A., Csizmadia, E., Palominos, M., Stiehm, A., Ebralidze, A., Chen, S. Y., Bassal, M. A., Zhao, P., Tolosano, E., Hurley, L., Bjartell, A., Tenen, D. G., & Wegiel, B. (2020). Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Reports, 32(12), Article 108181. https://doi.org/10.1016/j.celrep.2020.108181

Canesin, G, Di Ruscio, A, Li, M, Ummarino, S, Hedblom, A, Choudhury, R, Krzyzanowska, A, Csizmadia, E, Palominos, M, Stiehm, A, Ebralidze, A, Chen, SY, Bassal, MA, Zhao, P, Tolosano, E, Hurley, L, Bjartell, A, Tenen, DG & Wegiel, B 2020, 'Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases', Cell Reports, vol. 32, no. 12, 108181. https://doi.org/10.1016/j.celrep.2020.108181

@article{40bab53bf9dc4696971e76741f3d93ce,

title = "Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases",

abstract = "Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.",

keywords = "DNA G-quadruplexes, c-myc, heme, heme oxygenase-1, hemopexin, metastases, prostate cancer",

author = "Giacomo Canesin and \{Di Ruscio\}, Annalisa and Mailin Li and Simone Ummarino and Andreas Hedblom and Reeham Choudhury and Agnieszka Krzyzanowska and Eva Csizmadia and Macarena Palominos and Anna Stiehm and Alexander Ebralidze and Chen, \{Shao Yong\} and Bassal, \{Mahmoud A.\} and Ping Zhao and Emanuela Tolosano and Laurence Hurley and Anders Bjartell and Tenen, \{Daniel G.\} and Barbara Wegiel",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = sep,

day = "22",

doi = "10.1016/j.celrep.2020.108181",

language = "English (US)",

volume = "32",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "12",

}

TY - JOUR

T1 - Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

AU - Canesin, Giacomo

AU - Di Ruscio, Annalisa

AU - Li, Mailin

AU - Ummarino, Simone

AU - Hedblom, Andreas

AU - Choudhury, Reeham

AU - Krzyzanowska, Agnieszka

AU - Csizmadia, Eva

AU - Palominos, Macarena

AU - Stiehm, Anna

AU - Ebralidze, Alexander

AU - Chen, Shao Yong

AU - Bassal, Mahmoud A.

AU - Zhao, Ping

AU - Tolosano, Emanuela

AU - Hurley, Laurence

AU - Bjartell, Anders

AU - Tenen, Daniel G.

AU - Wegiel, Barbara

PY - 2020/9/22

Y1 - 2020/9/22

N2 - Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

AB - Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

KW - DNA G-quadruplexes

KW - c-myc

KW - heme

KW - heme oxygenase-1

KW - hemopexin

KW - metastases

KW - prostate cancer

UR - https://www.scopus.com/pages/publications/85091221510

UR - https://www.scopus.com/pages/publications/85091221510#tab=citedBy

U2 - 10.1016/j.celrep.2020.108181

DO - 10.1016/j.celrep.2020.108181

M3 - Article

C2 - 32966797

AN - SCOPUS:85091221510

SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

IS - 12

M1 - 108181

ER -

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this