SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

Raphael N. Vuille-dit-Bille; Kenneth W. Liechty; François Verrey; Laura C. Guglielmetti

doi:10.1007/s00726-020-02870-z

SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

Raphael N. Vuille-dit-Bille
, Kenneth W. Liechty
, François Verrey
, Laura C. Guglielmetti

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients’ age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman’s r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.

Original language	English (US)
Pages (from-to)	1063-1065
Number of pages	3
Journal	Amino Acids
Volume	52
Issue number	6-7
DOIs	https://doi.org/10.1007/s00726-020-02870-z
State	Published - Jul 1 2020
Externally published	Yes

Keywords

ACE2
Age
COVID-19
SARS-CoV-2

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Clinical Biochemistry

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10.1007/s00726-020-02870-z

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title = "SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age",

abstract = "Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients{\textquoteright} age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman{\textquoteright}s r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.",

keywords = "ACE2, Age, COVID-19, SARS-CoV-2",

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note = "Publisher Copyright: {\textcopyright} 2020, Springer-Verlag GmbH Austria, part of Springer Nature.",

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doi = "10.1007/s00726-020-02870-z",

language = "English (US)",

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AU - Vuille-dit-Bille, Raphael N.

AU - Liechty, Kenneth W.

AU - Verrey, François

AU - Guglielmetti, Laura C.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients’ age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman’s r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.

AB - Gastrointestinal symptoms are common in COVID-19 patients, especially in younger patients. Our hypothesis was that intestinal SARS-CoV-2 receptor ACE2 expression depends on patients’ age. We examined duodenal biopsies from 43 healthy human adults. ACE2 gene expression was directly correlated with age (Spearman’s r = 0.317, p = 0.039). With each year, duodenal ACE2 expression increased by 0.083 RU. The higher intestinal ACE2 mRNA expression in older patients may impact on their susceptibility to develop intestinal symptoms.

KW - ACE2

KW - Age

KW - COVID-19

KW - SARS-CoV-2

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ER -

SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age

Abstract

Keywords

ASJC Scopus subject areas

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