Abstract
Studies were conducted to determine if ISDN antagonizes the contractile responses to calcium of chemically-skinned aortic smooth muscle preparations. Isosorbide dinitrate relaxed intact aortic smooth muscle segments in a dose-dependent manner (0.01-100 μM). At all concentrations tested, ISDN was unable to relax triton-skinned smooth muscle preparations. However, the tension development of skinned preparations was inhibited by trifluoperazine (10 μM), a calmodulin antagonist. These results suggest that the relaxation of intact aortic smooth muscle preparations induced by ISDN is not related to an interference with calmodulin-dependent contractile events.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-205 |
| Number of pages | 11 |
| Journal | Research Communications in Chemical Pathology and Pharmacology |
| Volume | 52 |
| Issue number | 2 |
| State | Published - 1986 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Pharmacology
- Pharmacology, Toxicology and Pharmaceutics(all)