(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

Kui Mei; Shilei Zhang; Songtao He; Ping Li; Mei Jin; Fei Xue; Guangshun Luo; Haoyi Zhang; Lirong Song; Wenhu Duan; Wei Wang

doi:10.1016/j.tetlet.2008.02.164

(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

Kui Mei, Shilei Zhang, Songtao He, Ping Li, Mei Jin, Fei Xue, Guangshun Luo, Haoyi Zhang, Lirong Song, Wenhu Duan, Wei Wang

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

A (S)-pyrrolidine sulfonamide catalyzed asymmetric direct aldol reaction of aryl methyl ketones with aromatic aldehydes has been developed with moderate to good enantioselectivities. The study considerably broadens the substrate scope of chiral amines promoted aldol processes.

Original language	English (US)
Pages (from-to)	2681-2684
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	17
DOIs	https://doi.org/10.1016/j.tetlet.2008.02.164
State	Published - Apr 21 2008
Externally published	Yes

Keywords

Aldol reaction
Aryl alkyl ketones
Pyrrolidine sulfonamide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2008.02.164

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title = "(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes",

abstract = "A (S)-pyrrolidine sulfonamide catalyzed asymmetric direct aldol reaction of aryl methyl ketones with aromatic aldehydes has been developed with moderate to good enantioselectivities. The study considerably broadens the substrate scope of chiral amines promoted aldol processes.",

keywords = "Aldol reaction, Aryl alkyl ketones, Pyrrolidine sulfonamide",

author = "Kui Mei and Shilei Zhang and Songtao He and Ping Li and Mei Jin and Fei Xue and Guangshun Luo and Haoyi Zhang and Lirong Song and Wenhu Duan and Wei Wang",

note = "Funding Information: This work was supported by Shanghai Basic Research Project from the Shanghai Science and Technology Commission (Grants 06JC14080) and start-up funding from School of Pharmacy, East China University of Science and Technology. ",

year = "2008",

month = apr,

day = "21",

doi = "10.1016/j.tetlet.2008.02.164",

language = "English (US)",

volume = "49",

pages = "2681--2684",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "17",

}

TY - JOUR

T1 - (S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

AU - Mei, Kui

AU - Zhang, Shilei

AU - He, Songtao

AU - Li, Ping

AU - Jin, Mei

AU - Xue, Fei

AU - Luo, Guangshun

AU - Zhang, Haoyi

AU - Song, Lirong

AU - Duan, Wenhu

AU - Wang, Wei

N1 - Funding Information: This work was supported by Shanghai Basic Research Project from the Shanghai Science and Technology Commission (Grants 06JC14080) and start-up funding from School of Pharmacy, East China University of Science and Technology.

PY - 2008/4/21

Y1 - 2008/4/21

N2 - A (S)-pyrrolidine sulfonamide catalyzed asymmetric direct aldol reaction of aryl methyl ketones with aromatic aldehydes has been developed with moderate to good enantioselectivities. The study considerably broadens the substrate scope of chiral amines promoted aldol processes.

AB - A (S)-pyrrolidine sulfonamide catalyzed asymmetric direct aldol reaction of aryl methyl ketones with aromatic aldehydes has been developed with moderate to good enantioselectivities. The study considerably broadens the substrate scope of chiral amines promoted aldol processes.

KW - Aldol reaction

KW - Aryl alkyl ketones

KW - Pyrrolidine sulfonamide

UR - http://www.scopus.com/inward/record.url?scp=41249097546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41249097546&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2008.02.164

DO - 10.1016/j.tetlet.2008.02.164

M3 - Article

AN - SCOPUS:41249097546

SN - 0040-4039

VL - 49

SP - 2681

EP - 2684

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 17

ER -

(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

Abstract

Keywords

ASJC Scopus subject areas

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