(S)-Pyrrolidine sulfonamide catalyzed asymmetric direct aldol reactions of aryl methyl ketones with aryl aldehydes

Kui Mei, Shilei Zhang, Songtao He, Ping Li, Mei Jin, Fei Xue, Guangshun Luo, Haoyi Zhang, Lirong Song, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

A (S)-pyrrolidine sulfonamide catalyzed asymmetric direct aldol reaction of aryl methyl ketones with aromatic aldehydes has been developed with moderate to good enantioselectivities. The study considerably broadens the substrate scope of chiral amines promoted aldol processes.

Original languageEnglish (US)
Pages (from-to)2681-2684
Number of pages4
JournalTetrahedron Letters
Volume49
Issue number17
DOIs
StatePublished - Apr 21 2008
Externally publishedYes

Keywords

  • Aldol reaction
  • Aryl alkyl ketones
  • Pyrrolidine sulfonamide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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