@article{e16f4068282146a4b37c18ba9f457d60,
title = "Runs of homozygosity implicate autozygosity as a schizophrenia risk factor",
abstract = "Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by ~17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.",
author = "{The Schizophrenia Psychiatric Genome-Wide Association Study Consortium} and Keller, {Matthew C.} and Simonson, {Matthew A.} and Stephan Ripke and Neale, {Ben M.} and Gejman, {Pablo V.} and Howrigan, {Daniel P.} and Lee, {Sang Hong} and Todd Lencz and Levinson, {Douglas F.} and Sullivan, {Patrick F.} and {St Clair}, David and Sven Cichon and Marcella Rietschel and N{\"o}then, {Markus M.} and Wolfgang Maier and Schulze, {Thomas G.} and Manuel Mattheisen and Kirov, {George K.} and O{\textquoteright}Donovan, {Michael C.} and Holmans, {Peter A.} and Lyudmila Georgieva and Ivan Nikolov and Williams, {Hywel J.} and Draga Toncheva and Vihra Milanova and Owen, {Michael J.} and Nicholas Craddock and Marian Hamshere and Valentina Moskvina and Sarah Dwyer and Stan Zammit and Lin, {Dan Yu} and {van den Oord}, Edwin and Yunjung Kim and {Scott Stroup}, T. and Lieberman, {Jeffrey A.} and Thomas Hansen and Andr{\'e}s Ingason and Line Olsen and Henriette Schmock and Celina Skj{\o}dt and Thygesen, {Johan Hilge} and Anders Rosengren and Thomas Werge and Morris, {Derek W.} and O{\textquoteright}Dushlaine, {Colm T.} and Elaine Kenny and Quinn, {Emma M.} and Michael Gill and Ayman Fanous",
note = "Funding Information: Statistical analyses were carried out on the Genetic Cluster Computer ( http://www.geneticcluster.org ) which is financially supported by the Netherlands Scientific Organization (NWO 480-05-003) along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam.",
year = "2012",
month = apr,
day = "1",
doi = "10.1371/journal.pgen.1002656",
language = "English (US)",
volume = "8",
journal = "PLoS genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "4",
}