Round window perfusion dynamics: Implications for intracochlear therapy

Sarah N. Bowe, Abraham Jacob

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Purpose of Review The treatments for inner ear diseases are evolving as the systemic administration of medication is replaced by novel intratympanic and intracochlear drug delivery. The current review explores the background and recent developments in this field. Recent Findings: Although still in various stages of clinical development, novel drug delivery techniques such as the Silverstein MicroWick, the round window microcatheter, biodegradable hydrogels, biopolymers, nanoparticles, newly designed cochlear implant arrays, osmotic mini/micro pumps, and reciprocating perfusion systems hold significant promise. Animal data suggest that sustained delivery systems have more reliable inner ear pharmacokinetics than both systemic administration and intratympanic injections. Summary: As research scientists advance technologies for treating inner ear diseases, drug delivery techniques must keep pace. Viable treatment options for sensorineural hearing loss, tinnitus, and vestibular disorders are on the horizon and may usher in a new golden age for otology.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
JournalCurrent Opinion in Otolaryngology and Head and Neck Surgery
Issue number5
StatePublished - Oct 2010
Externally publishedYes


  • drug delivery
  • inner ear
  • intracochlear
  • intratympanic
  • round window

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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