Roles of two homotetrameric kinesins in sea urchin embryonic cell division

Kitty K. Chui, Gregory C. Rogers, Anna M. Kashina, Karen P. Wedaman, David J. Sharp, Duy T. Nguyen, Fred Wilt, Jonathan M. Scholey

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


To improve our understanding of the roles of microtubule cross-linking motors in mitosis, we analyzed two sea urchin embryonic kinesin-related proteins. It is striking to note that both of these proteins behave as homotetramers, but one behaves as a more compact molecule than the other. These observations suggest that these two presumptive motors could cross-link microtubules into bundles with different spacing. Both motors localize to mitotic spindles, and antibody microinjection experiments suggest that they have mitotic functions. Thus, one of these kinesin-related proteins may cross-link spindle microtubules into loose bundles that are 'tightened' by the other.

Original languageEnglish (US)
Pages (from-to)38005-38011
Number of pages7
JournalJournal of Biological Chemistry
Issue number48
StatePublished - Dec 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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