Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat

C. J. Robinson; E. Spanos; M. F. James; J. W. Pike; M. R. Haussler; A. M. Makeen; C. J. Hillyard; I. MacIntyre

doi:10.1677/joe.0.0940443

Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat

C. J. Robinson, E. Spanos, M. F. James, J. W. Pike, M. R. Haussler, A. M. Makeen, C. J. Hillyard, I. MacIntyre

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)₂D₃) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)₂D₃ and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)₂D₃ and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)₂D₃ which are responsible for the enhanced intestinal calcium absorption.

Original language	English (US)
Pages (from-to)	443-453
Number of pages	11
Journal	Unknown Journal
Volume	94
Issue number	3
DOIs	https://doi.org/10.1677/joe.0.0940443
State	Published - 1982

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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abstract = "Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.",

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AU - Robinson, C. J.

AU - Spanos, E.

AU - James, M. F.

AU - Pike, J. W.

AU - Haussler, M. R.

AU - Makeen, A. M.

AU - Hillyard, C. J.

AU - MacIntyre, I.

PY - 1982

Y1 - 1982

N2 - Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.

AB - Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.

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Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat

Abstract

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