Role of gender in regulation of redox homeostasis in pulmonary arterial hypertension

Ruslan Rafikov, Joel James, Nolan McClain, Stevan P. Tofovic, Olga Rafikova

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.

Original languageEnglish (US)
Article number135
JournalAntioxidants
Volume8
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Antioxidants
  • Cpulmonary hypertension
  • Gender difference
  • Oxidation
  • Redox homeostasis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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