Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man

Ella M. Nikulina; Damira F. Avgustinovich; Nina K. Popova

doi:10.1002/1098-2337(1992)18:5<357::AID-AB2480180505>3.0.CO;2-C

Role of 5HT_1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man

Ella M. Nikulina, Damira F. Avgustinovich, Nina K. Popova

Basic Medical Sciences, Phoenix

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The 5HT_1A receptor agonist ipsapirone (10 mg/kg) suppressed shock‐induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [³H]8‐OH‐DPAT binding, which labels 5HT_1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts, while 5HT_1A density was unchanged in the frontal cortex in domesticated animals. In essence, the aggressive reactions contributing to the defensive behavior complex in wild rats appear to be regulated through 5HT_1A receptors. © 1992 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	357-364
Number of pages	8
Journal	Aggressive behavior
Volume	18
Issue number	5
DOIs	https://doi.org/10.1002/1098-2337(1992)18:5<357::AID-AB2480180505>3.0.CO;2-C
State	Published - 1992

Keywords

domestication
ipsapirone
neophobia
serotonin

ASJC Scopus subject areas

Developmental and Educational Psychology
Arts and Humanities (miscellaneous)
Psychology(all)

Access to Document

10.1002/1098-2337(1992)18:5<357::AID-AB2480180505>3.0.CO;2-C

Cite this

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title = "Role of 5HT1A receptors in a variety of kinds of aggressive behavior in wild rats and counterparts selected for low defensiveness towards man",

abstract = "The 5HT1A receptor agonist ipsapirone (10 mg/kg) suppressed shock‐induced aggression in wild and domesticated rats but did not affect predatory aggression in either group of animals. Ipsapirone decreased neophobia and inhibited defensive reactions by wild rats towards man in the glove test. [3H]8‐OH‐DPAT binding, which labels 5HT1A receptors, was significantly increased in the hypothalamus of domesticated rats in comparison with wild counterparts, while 5HT1A density was unchanged in the frontal cortex in domesticated animals. In essence, the aggressive reactions contributing to the defensive behavior complex in wild rats appear to be regulated through 5HT1A receptors. {\textcopyright} 1992 Wiley‐Liss, Inc.",

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