TY - JOUR
T1 - RNA-directed DNA methylation
T2 - An epigenetic pathway of increasing complexity
AU - Matzke, Marjori A.
AU - Mosher, Rebecca A.
N1 - Funding Information:
M.A.M. thanks Academia Sinica for financial support and C. Ying for editorial assistance. R.A.M. is supported by the US National Science Foundation under grant MCB-1243608. The authors apologize to colleagues whose publications are not cited owing to space limitations.
PY - 2014/6
Y1 - 2014/6
N2 - RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases-Pol IV and Pol V-and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.
AB - RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. RdDM requires a specialized transcriptional machinery that comprises two plant-specific RNA polymerases-Pol IV and Pol V-and a growing number of accessory proteins, the functions of which in the RdDM mechanism are only partially understood. Recent work has revealed variations in the canonical RdDM pathway and identified factors that recruit Pol IV and Pol V to specific target sequences. RdDM, which transcriptionally represses a subset of transposons and genes, is implicated in pathogen defence, stress responses and reproduction, as well as in interallelic and intercellular communication.
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U2 - 10.1038/nrg3683
DO - 10.1038/nrg3683
M3 - Review article
C2 - 24805120
AN - SCOPUS:84901041535
SN - 1471-0056
VL - 15
SP - 394
EP - 408
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 6
ER -