Risk factors for disseminated coccidioidomycosis, United States

Camila D. Odio; Beatriz E. Marciano; John N. Galgiani; Steven M. Holland

doi:10.3201/eid2302.160505

Risk factors for disseminated coccidioidomycosis, United States

Camila D. Odio
, Beatriz E. Marciano
, John N. Galgiani
, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.

Original language	English (US)
Pages (from-to)	308-311
Number of pages	4
Journal	Emerging infectious diseases
Volume	23
Issue number	2
DOIs	https://doi.org/10.3201/eid2302.160505
State	Published - Feb 2017

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Risk factors for disseminated coccidioidomycosis, United States",

abstract = "Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1\% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.",

author = "Odio, \{Camila D.\} and Marciano, \{Beatriz E.\} and Galgiani, \{John N.\} and Holland, \{Steven M.\}",

note = "Funding Information: This study was funded in part by the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases National Institutes of Health (NIH), USA. Publisher Copyright: {\textcopyright} 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.",

year = "2017",

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doi = "10.3201/eid2302.160505",

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AU - Odio, Camila D.

AU - Marciano, Beatriz E.

AU - Galgiani, John N.

AU - Holland, Steven M.

N1 - Funding Information: This study was funded in part by the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases National Institutes of Health (NIH), USA. Publisher Copyright: © 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.

PY - 2017/2

Y1 - 2017/2

N2 - Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.

AB - Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.

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Risk factors for disseminated coccidioidomycosis, United States

Abstract

ASJC Scopus subject areas

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