Review on the systemic delivery of insulin via the ocular route

Yung Chi Lee, Pahala Simamora, Sirirat Pinsuwan, Samuel H. Yalkowsky

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Systemic drug absorption from the ocular route is well known. Although there is some absorption from the conjunctival sac, the nasal meatus is the site where the majority of systemic absorption of instilled drug takes place. This article reviews the principles of systemic absorption of insulin applied topically to the eye. The physiological and pharmaceutical considerations for formulation development and the strategy of improving the systemic absorption and bioavailability of insulin are also discussed.

Original languageEnglish (US)
Pages (from-to)1-18
Number of pages18
JournalInternational Journal of Pharmaceutics
Issue number1-2
StatePublished - Feb 21 2002


  • Insulin
  • Ocular route
  • Systemic absorption

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Review on the systemic delivery of insulin via the ocular route'. Together they form a unique fingerprint.

Cite this