Review of bio-optical imaging systems with a high space-bandwidth product

Jongchan Park, David J. Brady, Guoan Zheng, Lei Tian, Liang Gao

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Optical imaging has served as a primary method to collect information about biosystems across scales-from functionalities of tissues to morphological structures of cells and even at biomolecular levels. However, to adequately characterize a complex biosystem, an imaging system with a number of resolvable points, referred to as a space-bandwidth product (SBP), in excess of one billion is typically needed. Since a gigapixel-scale far exceeds the capacity of current optical imagers, compromises must be made to obtain either a low spatial resolution or a narrow field-of-view (FOV). The problem originates from constituent refractive optics-the larger the aperture, the more challenging the correction of lens aberrations. Therefore, it is impractical for a conventional optical imaging system to achieve an SBP over hundreds of millions. To address this unmet need, a variety of high-SBP imagers have emerged over the past decade, enabling an unprecedented resolution and FOV beyond the limit of conventional optics. We provide a comprehensive survey of high-SBP imaging techniques, exploring their underlying principles and applications in bioimaging.

Original languageEnglish (US)
Article number044001
JournalAdvanced Photonics
Volume3
Issue number4
DOIs
StatePublished - Jul 1 2021
Externally publishedYes

Keywords

  • Bioimaging
  • Gigapixel imaging
  • High resolution
  • Space-bandwidth product
  • Wide field of view

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomedical Engineering

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