Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Retinoids play important roles in the ontogenic development of the olfactory system in mammals, but their function in adult olfactory mucosa has not been explored. In the present study, the olfactory mucosal expression of nuclear retinoid receptors was examined in adult mice. Several retinoic acid receptor isotypes were identified in olfactory mucosa from adult C57BL/6 mice by RNA-PCR and DNA sequence analysis, including RARβ, RXRα, RXRβ, and RXRγ. In addition, a previously unidentified mouse RXRβ isoform containing a 12-nucleotide insertion in exon 7 was detected. Furthermore, in vitro metabolic studies demonstrated that olfactory mucosal cytosolic and microsomal preparations are active in the biosynthesis of retinoic acids from all-trans- and 9-cis-retinal. These results indicate that components of the retinoid signal transduction system are expressed in adult olfactory mucosa and may play important roles in gene regulation in this unique tissue where olfactory neuronal cells are continuously replaced.

Original languageEnglish (US)
Pages (from-to)346-351
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Mar 16 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Retinoic acid biosynthetic activity and retinoid receptors in the olfactory mucosa of adult mice'. Together they form a unique fingerprint.

Cite this