Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Anne Elie Carsin; Elaine Fuertes; Emmanuel Schaffner; Debbie Jarvis; Josep M. Antó; Joachim Heinrich; Valeria Bellisario; Cecilie Svanes; Dirk Keidel; Medea Imboden; Joost Weyler; Dennis Nowak; Jesus Martinez-Moratalla; José Antonio Gullón; José Luis Sanchez Ramos; Seraina Caviezel; Anna Beckmeyer-Borowko; Chantal Raherison; Isabelle Pin; Pascal Demoly; Isa Cerveri; Simone Accordini; Thorarinn Gislason; Kjell Toren; Bertil Forsberg; Christer Janson; Rain Jogi; Margareta Emtner; Francisco Gómez Real; Wasif Raza; Bénédicte Leynaert; Silvia Pascual; Stefano Guerra; Shyamali C. Dharmage; Nicole Probst-Hensch; Judith Garcia-Aymerich

doi:10.1016/j.rmed.2018.11.017

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Anne Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Debbie Jarvis, Josep M. Antó, Joachim Heinrich, Valeria Bellisario, Cecilie Svanes, Dirk Keidel, Medea Imboden, Joost Weyler, Dennis Nowak, Jesus Martinez-Moratalla, José Antonio Gullón, José Luis Sanchez Ramos, Seraina Caviezel, Anna Beckmeyer-Borowko, Chantal Raherison, Isabelle Pin, Pascal DemolyIsa Cerveri, Simone Accordini, Thorarinn Gislason, Kjell Toren, Bertil Forsberg, Christer Janson, Rain Jogi, Margareta Emtner, Francisco Gómez Real, Wasif Raza, Bénédicte Leynaert, Silvia Pascual, Stefano Guerra, Shyamali C. Dharmage, Nicole Probst-Hensch, Judith Garcia-Aymerich

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry. Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV₁/FVC ≥ Lower Limit of Normal and a FVC<80% predicted in two population-based studies (ECRHS-III and SAPALDIA3). Physical activity was measured using the International Physical Activity Questionnaire. The odds of having low physical activity (<1st study-specific tertile) was evaluated using adjusted logistic regression models. Results: Subjects with a restrictive spirometry pattern (n = 280/4721 in ECRHS, n = 143/3570 in SAPALDIA) reported lower levels of physical activity than those with normal spirometry (median of 1770 vs 2253 MET·min/week in ECRHS, and 3519 vs 3945 MET·min/week in SAPALDIA). Subjects with a restrictive spirometry pattern were more likely to report low physical activity (meta-analysis odds ratio: 1.41 [95%CI 1.07–1.86]) than those with a normal spirometry. Obesity, respiratory symptoms, co-morbidities and previous physical activity levels did not fully explain this finding. Conclusion: Adults with a restrictive spirometry pattern were more likely to report low levels of physical activity than those with normal spirometry. These results highlight the need to identify and act on this understudied but prevalent condition.

Original language	English (US)
Pages (from-to)	116-123
Number of pages	8
Journal	Respiratory Medicine
Volume	146
DOIs	https://doi.org/10.1016/j.rmed.2018.11.017
State	Published - Jan 2019

Keywords

Body mass index
Epidemiology
Lung function
Physical activity
Restrictive spirometry pattern

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2018.11.017

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Carsin, A. E., Fuertes, E., Schaffner, E., Jarvis, D., Antó, J. M., Heinrich, J., Bellisario, V., Svanes, C., Keidel, D., Imboden, M., Weyler, J., Nowak, D., Martinez-Moratalla, J., Gullón, J. A., Sanchez Ramos, J. L., Caviezel, S., Beckmeyer-Borowko, A., Raherison, C., Pin, I., ... Garcia-Aymerich, J. (2019). Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respiratory Medicine, 146, 116-123. https://doi.org/10.1016/j.rmed.2018.11.017

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. / Carsin, Anne Elie; Fuertes, Elaine; Schaffner, Emmanuel; Jarvis, Debbie; Antó, Josep M.; Heinrich, Joachim; Bellisario, Valeria; Svanes, Cecilie; Keidel, Dirk; Imboden, Medea; Weyler, Joost; Nowak, Dennis; Martinez-Moratalla, Jesus; Gullón, José Antonio; Sanchez Ramos, José Luis; Caviezel, Seraina; Beckmeyer-Borowko, Anna; Raherison, Chantal; Pin, Isabelle; Demoly, Pascal; Cerveri, Isa; Accordini, Simone; Gislason, Thorarinn; Toren, Kjell; Forsberg, Bertil; Janson, Christer; Jogi, Rain; Emtner, Margareta; Gómez Real, Francisco; Raza, Wasif; Leynaert, Bénédicte; Pascual, Silvia; Guerra, Stefano; Dharmage, Shyamali C.; Probst-Hensch, Nicole; Garcia-Aymerich, Judith.

In: Respiratory Medicine, Vol. 146, 01.2019, p. 116-123.

Research output: Contribution to journal › Article › peer-review

Carsin, AE, Fuertes, E, Schaffner, E, Jarvis, D, Antó, JM, Heinrich, J, Bellisario, V, Svanes, C, Keidel, D, Imboden, M, Weyler, J, Nowak, D, Martinez-Moratalla, J, Gullón, JA, Sanchez Ramos, JL, Caviezel, S, Beckmeyer-Borowko, A, Raherison, C, Pin, I, Demoly, P, Cerveri, I, Accordini, S, Gislason, T, Toren, K, Forsberg, B, Janson, C, Jogi, R, Emtner, M, Gómez Real, F, Raza, W, Leynaert, B, Pascual, S, Guerra, S, Dharmage, SC, Probst-Hensch, N & Garcia-Aymerich, J 2019, 'Restrictive spirometry pattern is associated with low physical activity levels. A population based international study', Respiratory Medicine, vol. 146, pp. 116-123. https://doi.org/10.1016/j.rmed.2018.11.017

Carsin, Anne Elie ; Fuertes, Elaine ; Schaffner, Emmanuel ; Jarvis, Debbie ; Antó, Josep M. ; Heinrich, Joachim ; Bellisario, Valeria ; Svanes, Cecilie ; Keidel, Dirk ; Imboden, Medea ; Weyler, Joost ; Nowak, Dennis ; Martinez-Moratalla, Jesus ; Gullón, José Antonio ; Sanchez Ramos, José Luis ; Caviezel, Seraina ; Beckmeyer-Borowko, Anna ; Raherison, Chantal ; Pin, Isabelle ; Demoly, Pascal ; Cerveri, Isa ; Accordini, Simone ; Gislason, Thorarinn ; Toren, Kjell ; Forsberg, Bertil ; Janson, Christer ; Jogi, Rain ; Emtner, Margareta ; Gómez Real, Francisco ; Raza, Wasif ; Leynaert, Bénédicte ; Pascual, Silvia ; Guerra, Stefano ; Dharmage, Shyamali C. ; Probst-Hensch, Nicole ; Garcia-Aymerich, Judith. / Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. In: Respiratory Medicine. 2019 ; Vol. 146. pp. 116-123.

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title = "Restrictive spirometry pattern is associated with low physical activity levels. A population based international study",

abstract = "Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry. Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV1/FVC ≥ Lower Limit of Normal and a FVC<80% predicted in two population-based studies (ECRHS-III and SAPALDIA3). Physical activity was measured using the International Physical Activity Questionnaire. The odds of having low physical activity (<1st study-specific tertile) was evaluated using adjusted logistic regression models. Results: Subjects with a restrictive spirometry pattern (n = 280/4721 in ECRHS, n = 143/3570 in SAPALDIA) reported lower levels of physical activity than those with normal spirometry (median of 1770 vs 2253 MET·min/week in ECRHS, and 3519 vs 3945 MET·min/week in SAPALDIA). Subjects with a restrictive spirometry pattern were more likely to report low physical activity (meta-analysis odds ratio: 1.41 [95%CI 1.07–1.86]) than those with a normal spirometry. Obesity, respiratory symptoms, co-morbidities and previous physical activity levels did not fully explain this finding. Conclusion: Adults with a restrictive spirometry pattern were more likely to report low levels of physical activity than those with normal spirometry. These results highlight the need to identify and act on this understudied but prevalent condition.",

keywords = "Body mass index, Epidemiology, Lung function, Physical activity, Restrictive spirometry pattern",

author = "Carsin, {Anne Elie} and Elaine Fuertes and Emmanuel Schaffner and Debbie Jarvis and Ant{\'o}, {Josep M.} and Joachim Heinrich and Valeria Bellisario and Cecilie Svanes and Dirk Keidel and Medea Imboden and Joost Weyler and Dennis Nowak and Jesus Martinez-Moratalla and Gull{\'o}n, {Jos{\'e} Antonio} and {Sanchez Ramos}, {Jos{\'e} Luis} and Seraina Caviezel and Anna Beckmeyer-Borowko and Chantal Raherison and Isabelle Pin and Pascal Demoly and Isa Cerveri and Simone Accordini and Thorarinn Gislason and Kjell Toren and Bertil Forsberg and Christer Janson and Rain Jogi and Margareta Emtner and {G{\'o}mez Real}, Francisco and Wasif Raza and B{\'e}n{\'e}dicte Leynaert and Silvia Pascual and Stefano Guerra and Dharmage, {Shyamali C.} and Nicole Probst-Hensch and Judith Garcia-Aymerich",

note = "Funding Information: Professor Jarvis reports grants from the Medical Research Council and European Commission during the conduct of this study. Dr. J{\~o}gi reports grants from Estonian Research Council during the conduct of the study. Dr. Garcia-Aymerich reports grants from European Commission during the conduct of the study.The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS II and ECRHS III) are reported in the Supplementary Material. SAPALDIA is funded by the National Science Foundation Grant Nr. 33CS30-177506. Elaine Fuertes was funded from the European Union's Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268). ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. Funding Information: Professor Jarvis reports grants from the Medical Research Council and European Commission during the conduct of this study. Dr. J{\~o}gi reports grants from Estonian Research Council during the conduct of the study. Dr. Garcia-Aymerich reports grants from European Commission during the conduct of the study. Funding Information: The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study ( www.alecstudy.org ), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212 . The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS II and ECRHS III) are reported in the Supplementary Material. SAPALDIA is funded by the National Science Foundation Grant Nr. 33CS30-177506 . Elaine Fuertes was funded from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268 ). ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2019",

month = jan,

doi = "10.1016/j.rmed.2018.11.017",

language = "English (US)",

volume = "146",

pages = "116--123",

journal = "British Journal of Tuberculosis and Diseases of the Chest",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

AU - Carsin, Anne Elie

AU - Fuertes, Elaine

AU - Schaffner, Emmanuel

AU - Jarvis, Debbie

AU - Antó, Josep M.

AU - Heinrich, Joachim

AU - Bellisario, Valeria

AU - Svanes, Cecilie

AU - Keidel, Dirk

AU - Imboden, Medea

AU - Weyler, Joost

AU - Nowak, Dennis

AU - Martinez-Moratalla, Jesus

AU - Gullón, José Antonio

AU - Sanchez Ramos, José Luis

AU - Caviezel, Seraina

AU - Beckmeyer-Borowko, Anna

AU - Raherison, Chantal

AU - Pin, Isabelle

AU - Demoly, Pascal

AU - Cerveri, Isa

AU - Accordini, Simone

AU - Gislason, Thorarinn

AU - Toren, Kjell

AU - Forsberg, Bertil

AU - Janson, Christer

AU - Jogi, Rain

AU - Emtner, Margareta

AU - Gómez Real, Francisco

AU - Raza, Wasif

AU - Leynaert, Bénédicte

AU - Pascual, Silvia

AU - Guerra, Stefano

AU - Dharmage, Shyamali C.

AU - Probst-Hensch, Nicole

AU - Garcia-Aymerich, Judith

N1 - Funding Information: Professor Jarvis reports grants from the Medical Research Council and European Commission during the conduct of this study. Dr. Jõgi reports grants from Estonian Research Council during the conduct of the study. Dr. Garcia-Aymerich reports grants from European Commission during the conduct of the study.The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (www.alecstudy.org), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212. The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS II and ECRHS III) are reported in the Supplementary Material. SAPALDIA is funded by the National Science Foundation Grant Nr. 33CS30-177506. Elaine Fuertes was funded from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268). ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. Funding Information: Professor Jarvis reports grants from the Medical Research Council and European Commission during the conduct of this study. Dr. Jõgi reports grants from Estonian Research Council during the conduct of the study. Dr. Garcia-Aymerich reports grants from European Commission during the conduct of the study. Funding Information: The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study ( www.alecstudy.org ), which has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 633212 . The local investigators and funding agencies for the European Community Respiratory Health Survey (ECRHS II and ECRHS III) are reported in the Supplementary Material. SAPALDIA is funded by the National Science Foundation Grant Nr. 33CS30-177506 . Elaine Fuertes was funded from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Individual Fellowship scheme (H2020-MSCA-IF-2015; proposal number 704268 ). ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/1

Y1 - 2019/1

N2 - Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry. Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV1/FVC ≥ Lower Limit of Normal and a FVC<80% predicted in two population-based studies (ECRHS-III and SAPALDIA3). Physical activity was measured using the International Physical Activity Questionnaire. The odds of having low physical activity (<1st study-specific tertile) was evaluated using adjusted logistic regression models. Results: Subjects with a restrictive spirometry pattern (n = 280/4721 in ECRHS, n = 143/3570 in SAPALDIA) reported lower levels of physical activity than those with normal spirometry (median of 1770 vs 2253 MET·min/week in ECRHS, and 3519 vs 3945 MET·min/week in SAPALDIA). Subjects with a restrictive spirometry pattern were more likely to report low physical activity (meta-analysis odds ratio: 1.41 [95%CI 1.07–1.86]) than those with a normal spirometry. Obesity, respiratory symptoms, co-morbidities and previous physical activity levels did not fully explain this finding. Conclusion: Adults with a restrictive spirometry pattern were more likely to report low levels of physical activity than those with normal spirometry. These results highlight the need to identify and act on this understudied but prevalent condition.

AB - Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry. Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV1/FVC ≥ Lower Limit of Normal and a FVC<80% predicted in two population-based studies (ECRHS-III and SAPALDIA3). Physical activity was measured using the International Physical Activity Questionnaire. The odds of having low physical activity (<1st study-specific tertile) was evaluated using adjusted logistic regression models. Results: Subjects with a restrictive spirometry pattern (n = 280/4721 in ECRHS, n = 143/3570 in SAPALDIA) reported lower levels of physical activity than those with normal spirometry (median of 1770 vs 2253 MET·min/week in ECRHS, and 3519 vs 3945 MET·min/week in SAPALDIA). Subjects with a restrictive spirometry pattern were more likely to report low physical activity (meta-analysis odds ratio: 1.41 [95%CI 1.07–1.86]) than those with a normal spirometry. Obesity, respiratory symptoms, co-morbidities and previous physical activity levels did not fully explain this finding. Conclusion: Adults with a restrictive spirometry pattern were more likely to report low levels of physical activity than those with normal spirometry. These results highlight the need to identify and act on this understudied but prevalent condition.

KW - Body mass index

KW - Epidemiology

KW - Lung function

KW - Physical activity

KW - Restrictive spirometry pattern

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Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

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