Responsiveness of the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI)

K. J. Propert, M. S. Litwin, Y. Wang, R. B. Alexander, E. Calhoun, J. C. Nickel, M. P. O'Leary, M. Pontari, M. McNaughton-Collins

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. Methods: We studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and pain, urinary, and quality of life subscores were compared to a global response assessment (GRA). Effect sizes and Guyatt statistics were calculated to evaluate responsiveness; 95% confidence intervals were produced using bootstrapping. Results: All scores decreased over time with the largest decrease in subjects who reported on the GRA that they were markedly improved. The NIH-CPSI total, pain, and quality of life scores were highly responsive in the improved groups; the urinary score showed minimal responsiveness. There was no evidence of responsiveness among those subjects who worsened on the trial. ROC curves identified a 6-point decline in the NIH-CPSI total score as the optimal threshold to predict treatment response. Conclusions: The NIH-CPSI total score and pain and quality of life subscores are responsive to change over time.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalQuality of Life Research
Issue number2
StatePublished - Mar 2006


  • Chronic pelvic pain syndrome
  • Chronic prostatitis
  • Symptom index

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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